Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial.
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| Title: | Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial. |
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| Authors: | Lee RJ; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Rebecca.lee-3@manchester.ac.uk.; The Christie NHS Foundation Trust, Manchester, UK. Rebecca.lee-3@manchester.ac.uk., Rothwell DG; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Smith N; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Chow S; Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool, UK., Delgado-SanMartin J; NHLI Data Science, Imperial College London, London, UK.; Systems Forecasting, Manchester, UK., Mistry H; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Systems Forecasting, Manchester, UK., Sylvestre Y; Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Chiang SC; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Clarke H; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Gremel G; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK., Gupta A; The Christie NHS Foundation Trust, Manchester, UK., Hockenhull K; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK., Kelso N; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Kochhar R; The Christie NHS Foundation Trust, Manchester, UK., Mullan D; The Christie NHS Foundation Trust, Manchester, UK., Plummer R; Sir Bobby Robson Cancer Trials Research Centre, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK.; Newcastle University, Newcastle upon Tyne, UK., Serra P; The Christie NHS Foundation Trust, Manchester, UK., Shaw H; Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK., Summersgill H; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Turajlic S; Skin and Renal Units, The Royal Marsden NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK., Mouliere F; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Marais R; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.; Oncodrug Ltd, Macclesfield, UK., Dive C; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK., Lorigan P; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. paul.lorigan@nhs.net.; The Christie NHS Foundation Trust, Manchester, UK. paul.lorigan@nhs.net. |
| Source: | Nature communications [Nat Commun] 2026 May 21. Date of Electronic Publication: 2026 May 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42168180 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lee+RJ%22">Lee RJ</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Rebecca.lee-3@manchester.ac.uk.; The Christie NHS Foundation Trust, Manchester, UK. Rebecca.lee-3@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Rothwell+DG%22">Rothwell DG</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Smith+N%22">Smith N</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chow+S%22">Chow S</searchLink>; Department of Medical Oncology, Clatterbridge Cancer Centre, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Delgado-SanMartin+J%22">Delgado-SanMartin J</searchLink>; NHLI Data Science, Imperial College London, London, UK.; Systems Forecasting, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Mistry+H%22">Mistry H</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Systems Forecasting, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Sylvestre+Y%22">Sylvestre Y</searchLink>; Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Chiang+SC%22">Chiang SC</searchLink>; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+H%22">Clarke H</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Gremel+G%22">Gremel G</searchLink>; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hockenhull+K%22">Hockenhull K</searchLink>; Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Kelso+N%22">Kelso N</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Kochhar+R%22">Kochhar R</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Mullan+D%22">Mullan D</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Plummer+R%22">Plummer R</searchLink>; Sir Bobby Robson Cancer Trials Research Centre, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK.; Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Serra+P%22">Serra P</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+H%22">Shaw H</searchLink>; Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Summersgill+H%22">Summersgill H</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Turajlic+S%22">Turajlic S</searchLink>; Skin and Renal Units, The Royal Marsden NHS Foundation Trust, London, UK.; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Mouliere+F%22">Mouliere F</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Marais+R%22">Marais R</searchLink>; Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK.; Oncodrug Ltd, Macclesfield, UK.<br /><searchLink fieldCode="AU" term="%22Dive+C%22">Dive C</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Lorigan+P%22">Lorigan P</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. paul.lorigan@nhs.net.; The Christie NHS Foundation Trust, Manchester, UK. paul.lorigan@nhs.net. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 21. <i>Date of Electronic Publication: </i>2026 May 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42168180 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-72735-8 Languages: – Code: eng Text: English Titles: – TitleFull: Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lee RJ – PersonEntity: Name: NameFull: Rothwell DG – PersonEntity: Name: NameFull: Smith N – PersonEntity: Name: NameFull: Chow S – PersonEntity: Name: NameFull: Delgado-SanMartin J – PersonEntity: Name: NameFull: Mistry H – PersonEntity: Name: NameFull: Sylvestre Y – PersonEntity: Name: NameFull: Chiang SC – PersonEntity: Name: NameFull: Clarke H – PersonEntity: Name: NameFull: Gremel G – PersonEntity: Name: NameFull: Gupta A – PersonEntity: Name: NameFull: Hockenhull K – PersonEntity: Name: NameFull: Kelso N – PersonEntity: Name: NameFull: Kochhar R – PersonEntity: Name: NameFull: Mullan D – PersonEntity: Name: NameFull: Plummer R – PersonEntity: Name: NameFull: Serra P – PersonEntity: Name: NameFull: Shaw H – PersonEntity: Name: NameFull: Summersgill H – PersonEntity: Name: NameFull: Turajlic S – PersonEntity: Name: NameFull: Mouliere F – PersonEntity: Name: NameFull: Marais R – PersonEntity: Name: NameFull: Dive C – PersonEntity: Name: NameFull: Lorigan P IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 05 Text: 2026 May 21 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Titles: – TitleFull: Nature communications Type: main |
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