Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy.

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Title: Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy.
Authors: Li Z; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Xu S; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Jiang X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Yang X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Cui S; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Lu Y; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Duan X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Zheng J; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.
Source: International journal of nanomedicine [Int J Nanomedicine] 2026 May 16; Vol. 21, pp. 606369. Date of Electronic Publication: 2026 May 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1178-2013
DOI:10.2147/IJN.S606369