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Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy.

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Title: Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy.
Authors: Li Z; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Xu S; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Jiang X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Yang X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Cui S; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Lu Y; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Duan X; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China., Zheng J; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.
Source: International journal of nanomedicine [Int J Nanomedicine] 2026 May 16; Vol. 21, pp. 606369. Date of Electronic Publication: 2026 May 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tromethamine‑Modified Chlorambucil Prodrug Nano-Micelles: Improved Colloidal Stability and Antitumor Efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Cui+S%22">Cui S</searchLink>; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Provincial Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Shangdang Chinese Medicinal Materials, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Duan+X%22">Duan X</searchLink>; Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics, School of Pharmacy, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Shanxi Key Laboratory of Aging Mechanism Research and Translational Applications, Changzhi Medical College, Changzhi, Shanxi, 046000, People's Republic of China.
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  Data: <searchLink fieldCode="JN" term="%22101263847%22">International journal of nanomedicine</searchLink> [Int J Nanomedicine] 2026 May 16; Vol. 21, pp. 606369. <i>Date of Electronic Publication: </i>2026 May 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22DOVE+Medical+Press%22">DOVE Medical Press </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>101263847 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1178-2013 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211769114%22">11769114 </searchLink><i>NLM ISO Abbreviation: </i>Int J Nanomedicine <i>Subsets: </i>MEDLINE
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        Value: 10.2147/IJN.S606369
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              Text: 2026 May 16
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