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Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts.

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Title: Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts.
Authors: Javidnia S; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK., Roe JM; Department of Radiology and Nuclear Medicine, Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway.; Department of Psychology, Center for Lifespan Changes in Brain and Cognition (LCBC), University of Oslo, Oslo, Norway., Karhunen V; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Bell S; Department of Oncology, Precision Breast Cancer Institute, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Deak JD; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA., Levey D; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA., Kember RL; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA., Kranzler HR; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA., Cronjé HT; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Burgess S; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Gelernter J; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA., Ebmeier KP; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK., Topiwala A; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK.; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 May; Vol. 22 (5), pp. e71418.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Javidnia+S%22">Javidnia S</searchLink>; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK.<br /><searchLink fieldCode="AU" term="%22Roe+JM%22">Roe JM</searchLink>; Department of Radiology and Nuclear Medicine, Computational Radiology and Artificial Intelligence, Oslo University Hospital, Oslo, Norway.; Department of Psychology, Center for Lifespan Changes in Brain and Cognition (LCBC), University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Karhunen+V%22">Karhunen V</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gill+D%22">Gill D</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bell+S%22">Bell S</searchLink>; Department of Oncology, Precision Breast Cancer Institute, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Deak+JD%22">Deak JD</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Levey+D%22">Levey D</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Kember+RL%22">Kember RL</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kranzler+HR%22">Kranzler HR</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Cronjé+HT%22">Cronjé HT</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Burgess+S%22">Burgess S</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gelernter+J%22">Gelernter J</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Ebmeier+KP%22">Ebmeier KP</searchLink>; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK.<br /><searchLink fieldCode="AU" term="%22Topiwala+A%22">Topiwala A</searchLink>; Department of Psychiatry and Centre for Integrative Neuroimaging, University of Oxford, London, UK.; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
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