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RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.

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Title: RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.
Authors: Yao X; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Lin Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. linyunkaikely@163.com.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. linyunkaikely@163.com., Chen P; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Xu M; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Pei M; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Fan X; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Feng H; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Xing X; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Guo J; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Liu Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Quan X; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Pan Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Tan Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Zhou H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Dong L; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. dlw@smmu.edu.cn.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn.; Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, the Ministry of Education, No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn., Wang H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. wanghui_ehbh@163.com., Hu H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. huehbh@126.com.
Source: Molecular biomedicine [Mol Biomed] 2026 May 22; Vol. 7 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2662-8651
DOI:10.1186/s43556-026-00459-8