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RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.

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Title: RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.
Authors: Yao X; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Lin Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. linyunkaikely@163.com.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. linyunkaikely@163.com., Chen P; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Xu M; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Pei M; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Fan X; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Feng H; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China., Xing X; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Guo J; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Liu Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Quan X; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Pan Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Tan Y; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China., Zhou H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China., Dong L; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. dlw@smmu.edu.cn.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn.; Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, the Ministry of Education, No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn., Wang H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. wanghui_ehbh@163.com., Hu H; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. huehbh@126.com.
Source: Molecular biomedicine [Mol Biomed] 2026 May 22; Vol. 7 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis.
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  Data: <searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. linyunkaikely@163.com.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. linyunkaikely@163.com.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Pei+M%22">Pei M</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Fan+X%22">Fan X</searchLink>; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Feng+H%22">Feng H</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Xing+X%22">Xing X</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Quan+X%22">Quan X</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; National Center for Liver Cancer, Naval Medical University, No. 366 Qianju Road, Jiading, Shanghai, 201800, China. dlw@smmu.edu.cn.; International Cooperation Laboratory On Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn.; Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, the Ministry of Education, No. 225 Changhai Road, Yangpu, Shanghai, 200438, China. dlw@smmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. wanghui_ehbh@163.com.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), No. 700 Moyu North Road, Jiading, Shanghai, 201800, China. huehbh@126.com.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 May 22; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2026 May 22
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