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Distinct proteomic signatures of urinary extracellular vesicles link to albuminuria and treatment responses in diabetic kidney disease.

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Title: Distinct proteomic signatures of urinary extracellular vesicles link to albuminuria and treatment responses in diabetic kidney disease.
Authors: van Heugten MH; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands., Beckmann SB; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands., Salib M; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands., Curovic VR; Steno Diabetes Center Copenhagen, Herlev, Denmark., Beernink JM; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands., Faivre A; Department of Medicine and Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland., Laverman GD; Department of Internal Medicine, ZiekenhuisGroep Twente, Almelo, the Netherlands., Wu Q; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Bjornstad P; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and Division of Endocrinology, Department of Pediatrics, University of Washington, Seattle, Washington, USA., Hall AM; Institute of Anatomy and Zürich Kidney Center, University of Zürich, Zürich, Switzerland., Rossing P; Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Fenton RA; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Heerspink HJL; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands., Hoorn EJ; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: e.j.hoorn@erasmusmc.nl.
Source: Kidney international [Kidney Int] 2026 Aug; Vol. 110 (2), pp. 438-450. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE
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  Data: Distinct proteomic signatures of urinary extracellular vesicles link to albuminuria and treatment responses in diabetic kidney disease.
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  Data: <searchLink fieldCode="AU" term="%22van+Heugten+MH%22">van Heugten MH</searchLink>; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Beckmann+SB%22">Beckmann SB</searchLink>; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Salib+M%22">Salib M</searchLink>; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Curovic+VR%22">Curovic VR</searchLink>; Steno Diabetes Center Copenhagen, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Beernink+JM%22">Beernink JM</searchLink>; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Faivre+A%22">Faivre A</searchLink>; Department of Medicine and Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laverman+GD%22">Laverman GD</searchLink>; Department of Internal Medicine, ZiekenhuisGroep Twente, Almelo, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjornstad+P%22">Bjornstad P</searchLink>; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, and Division of Endocrinology, Department of Pediatrics, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Hall+AM%22">Hall AM</searchLink>; Institute of Anatomy and Zürich Kidney Center, University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rossing+P%22">Rossing P</searchLink>; Steno Diabetes Center Copenhagen, Herlev, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fenton+RA%22">Fenton RA</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Heerspink+HJL%22">Heerspink HJL</searchLink>; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoorn+EJ%22">Hoorn EJ</searchLink>; Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: e.j.hoorn@erasmusmc.nl.
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  Data: <searchLink fieldCode="JN" term="%220323470%22">Kidney international</searchLink> [Kidney Int] 2026 Aug; Vol. 110 (2), pp. 438-450. <i>Date of Electronic Publication: </i>2026 May 21.
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              Text: 2026 Aug
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