Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.
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| Title: | Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction. |
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| Authors: | Hasegawa K; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Hama N; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan.; Department of Clinical Laboratory Science, Sanyo Women's College, Hiroshima, Japan., Amemiya M; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Zeng C; Faculty of Science and Engineering, Waseda University, Tokyo, Japan., Ito Y; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Suzuki S; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Nakamura K; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Kondo J; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Takeda C; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan., Kurihara Y; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan., Ikeda K; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Fujita Y; Department of Developmental Biology, School of Medicine, Shimane University, Izumo, Japan., Okada Y; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Cell Polarity Regulation, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan.; Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan.; Universal Biology Institute (UBI), The University of Tokyo, Tokyo, Japan.; International Research Center for Neurointelligence (WPI-IRCN), Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan., Toyoda A; Comparative Genomics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan., Hamada M; Faculty of Science and Engineering, Waseda University, Tokyo, Japan.; AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology, Tokyo, Japan., Kuwako KI; Department of Neural and Muscular Physiology, School of Medicine, Shimane University, Izumo, Japan. kuwako@med.shimane-u.ac.jp. |
| Source: | EMBO reports [EMBO Rep] 2026 Jul; Vol. 27 (13), pp. 3788-3825. Date of Electronic Publication: 2026 May 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-026-00786-5 |
