A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance.

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Title: A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance.
Authors: Zhou J; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Lou V; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhao Y; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Tang L; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Hu Z; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Sun J; State Key Laboratory of Natural Medicine, Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China., Chen J; Department of Emergency/Critical Care Medicine, Children's Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, China., Cheng P; Department:School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China., Cheng Y; Department of Pharmacy, Fujian Medical University Union Hospital, No.29 Xin Quan Road, Fuzhou, 350001, Fujian, China. chengyu@fjmu.edu.cn., He H; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. huahe_cpupk@cpu.edu.cn.
Source: The AAPS journal [AAPS J] 2026 May 23; Vol. 28 (4). Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-7416
DOI:10.1208/s12248-026-01255-6