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A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance.

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Title: A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance.
Authors: Zhou J; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Lou V; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Zhao Y; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Tang L; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Hu Z; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China., Sun J; State Key Laboratory of Natural Medicine, Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China., Chen J; Department of Emergency/Critical Care Medicine, Children's Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, China., Cheng P; Department:School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China., Cheng Y; Department of Pharmacy, Fujian Medical University Union Hospital, No.29 Xin Quan Road, Fuzhou, 350001, Fujian, China. chengyu@fjmu.edu.cn., He H; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. huahe_cpupk@cpu.edu.cn.
Source: The AAPS journal [AAPS J] 2026 May 23; Vol. 28 (4). Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Lou+V%22">Lou V</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Hu+Z%22">Hu Z</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; State Key Laboratory of Natural Medicine, Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Emergency/Critical Care Medicine, Children's Hospital of Nanjing Medical University, No. 72 GuangZhou Road, Nanjing, Jiangsu Province, 210008, China.<br /><searchLink fieldCode="AU" term="%22Cheng+P%22">Cheng P</searchLink>; Department:School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China.<br /><searchLink fieldCode="AU" term="%22Cheng+Y%22">Cheng Y</searchLink>; Department of Pharmacy, Fujian Medical University Union Hospital, No.29 Xin Quan Road, Fuzhou, 350001, Fujian, China. chengyu@fjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. huahe_cpupk@cpu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 May 23; Vol. 28 (4). <i>Date of Electronic Publication: </i>2026 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE
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        Value: 10.1208/s12248-026-01255-6
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        Text: English
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              Text: 2026 May 23
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