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Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.

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Bibliographic Details
Title: Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.
Authors: Di Franco R; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Mottareale R; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy. rocco.mottareale@istitutotumori.na.it., Pezzulla D; Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy., Mercogliano S; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Borzillo V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Scipilliti E; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Silvestro G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., De Palma G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Serra M; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Ametrano G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Buonanno F; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Arrichiello C; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., d'Alesio V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., di Franco MA; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Cilla S; Medical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy., Cuomo A; Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Maranzano E; University of Perugia, Perugia, Italy., Donati C; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Cellini F; Dipartimento di Diagnostica per Immagini, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC di Radioterapia Oncologica ed Ematologia, Rome, Italy., Ravo V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.
Source: Radiation oncology (London, England) [Radiat Oncol] 2026 May 22; Vol. 21 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1748-717X
DOI:10.1186/s13014-026-02860-7