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Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.

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Title: Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.
Authors: Di Franco R; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Mottareale R; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy. rocco.mottareale@istitutotumori.na.it., Pezzulla D; Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy., Mercogliano S; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Borzillo V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Scipilliti E; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Silvestro G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., De Palma G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Serra M; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Ametrano G; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Buonanno F; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Arrichiello C; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., d'Alesio V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., di Franco MA; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Cilla S; Medical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy., Cuomo A; Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy., Maranzano E; University of Perugia, Perugia, Italy., Donati C; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy., Cellini F; Dipartimento di Diagnostica per Immagini, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC di Radioterapia Oncologica ed Ematologia, Rome, Italy., Ravo V; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.
Source: Radiation oncology (London, England) [Radiat Oncol] 2026 May 22; Vol. 21 (1). Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatially fractionated radiation therapy for bulky tumors: a systematic review of clinical outcomes and dosimetric challenges.
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  Data: <searchLink fieldCode="AU" term="%22Di+Franco+R%22">Di Franco R</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Mottareale+R%22">Mottareale R</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy. rocco.mottareale@istitutotumori.na.it.<br /><searchLink fieldCode="AU" term="%22Pezzulla+D%22">Pezzulla D</searchLink>; Radiation Oncology Unit, Responsible Research Hospital, Campobasso, Italy.<br /><searchLink fieldCode="AU" term="%22Mercogliano+S%22">Mercogliano S</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Borzillo+V%22">Borzillo V</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Scipilliti+E%22">Scipilliti E</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Silvestro+G%22">Silvestro G</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22De+Palma+G%22">De Palma G</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Serra+M%22">Serra M</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Ametrano+G%22">Ametrano G</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Buonanno+F%22">Buonanno F</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Arrichiello+C%22">Arrichiello C</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22d'Alesio+V%22">d'Alesio V</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22di+Franco+MA%22">di Franco MA</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Cilla+S%22">Cilla S</searchLink>; Medical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro Cuore, Campobasso, Italy.<br /><searchLink fieldCode="AU" term="%22Cuomo+A%22">Cuomo A</searchLink>; Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Cavalcanti+E%22">Cavalcanti E</searchLink>; Laboratory Medicine Unit, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Maranzano+E%22">Maranzano E</searchLink>; University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Donati+C%22">Donati C</searchLink>; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cellini+F%22">Cellini F</searchLink>; Dipartimento di Diagnostica per Immagini, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC di Radioterapia Oncologica ed Ematologia, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ravo+V%22">Ravo V</searchLink>; Department of Radiation Oncology, Istituto Nazionale Tumori - IRCCS Fondazione 'G. Pascale', Napoli, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101265111%22">Radiation oncology (London, England)</searchLink> [Radiat Oncol] 2026 May 22; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 May 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101265111 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1748-717X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221748717X%22">1748717X </searchLink><i>NLM ISO Abbreviation: </i>Radiat Oncol <i>Subsets: </i>MEDLINE
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