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Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches.

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Title: Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches.
Authors: Kollár L; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary., Mihalovits LM; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary., Bajusz D; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary., Knez D; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Simon J; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; MS Metabolomics Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary., Balcomb BH; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK., Fearon D; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK., Gobec S; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia., Keserű GM; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary.
Source: ChemMedChem [ChemMedChem] 2026 May 27; Vol. 21 (10), pp. e202501108.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
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  Data: Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches.
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  Data: <searchLink fieldCode="AU" term="%22Kollár+L%22">Kollár L</searchLink>; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Mihalovits+LM%22">Mihalovits LM</searchLink>; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Bajusz+D%22">Bajusz D</searchLink>; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Knez+D%22">Knez D</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Simon+J%22">Simon J</searchLink>; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; MS Metabolomics Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Balcomb+BH%22">Balcomb BH</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Fearon+D%22">Fearon D</searchLink>; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Gobec+S%22">Gobec S</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Keserű+GM%22">Keserű GM</searchLink>; Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary.
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