Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.
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| Title: | Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity. |
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| Authors: | Overdijk MB; Genmab B.V., Utrecht, the Netherlands., Strumane K; Genmab B.V., Utrecht, the Netherlands., Plummer R; Newcastle University Translational and Clinical Research Institute, Medical School, Newcastle University, Newcastle upon Tyne, UK., LoRusso P; Yale Cancer Center, Yale University, New Haven, Connecticut, USA., Rodon Ahnert J; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Banerji U; Institute of Cancer Research and the Royal Marsden, London, UK., Garralda E; Early Drug Development Unit, Vall d'Hebron Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Calvo E; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain., Si H; Genmab US, Inc., Plainsboro, New Jersey, USA., Hoevenaars N; Genmab B.V., Utrecht, the Netherlands., Mortensen JT; Genmab A/S, Copenhagen, Denmark., Bosgra S; Genmab B.V., Utrecht, the Netherlands., Malmberg A; Genmab A/S, Copenhagen, Denmark., Ellekilde-Pedersen M; Genmab A/S, Copenhagen, Denmark., Ramirez-Andersen T; Genmab A/S, Copenhagen, Denmark., Diamantopoulou Reiter P; Genmab A/S, Copenhagen, Denmark., Favaro E; Genmab A/S, Copenhagen, Denmark., Forssmann U; Genmab A/S, Copenhagen, Denmark., Breij ECW; Genmab B.V., Utrecht, the Netherlands., Jure-Kunkel M; Genmab US, Inc., Plainsboro, New Jersey, USA. |
| Source: | Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70546. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study |
| Journal Info: | Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1752-8062 |
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| DOI: | 10.1111/cts.70546 |
