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Multiparametric MRI biomarkers in pediatric osteosarcoma: associations of ADC, necrosis, and tumor volume with histologic and clinical outcomes in a retrospective cohort study.

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Title: Multiparametric MRI biomarkers in pediatric osteosarcoma: associations of ADC, necrosis, and tumor volume with histologic and clinical outcomes in a retrospective cohort study.
Authors: Cruz IAND; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil. isabela.cruz@grupofleury.com.br.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil. isabela.cruz@grupofleury.com.br., Fayad LM; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, USA., Macedo CRPD; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil., Perez PTK; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil., Pinto MBR; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil., Azevedo BH; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil., Carvalho AG; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil., Lederman HM; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil., Fernandes ARC; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil., Guimarães JB; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil.; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil.
Source: Pediatric radiology [Pediatr Radiol] 2026 Jun; Vol. 56 (7), pp. 1572-1587. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0365332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1998 (Electronic) Linking ISSN: 03010449 NLM ISO Abbreviation: Pediatr Radiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiparametric MRI biomarkers in pediatric osteosarcoma: associations of ADC, necrosis, and tumor volume with histologic and clinical outcomes in a retrospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Cruz+IAND%22">Cruz IAND</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil. isabela.cruz@grupofleury.com.br.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil. isabela.cruz@grupofleury.com.br.<br /><searchLink fieldCode="AU" term="%22Fayad+LM%22">Fayad LM</searchLink>; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Macedo+CRPD%22">Macedo CRPD</searchLink>; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Perez+PTK%22">Perez PTK</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinto+MBR%22">Pinto MBR</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Azevedo+BH%22">Azevedo BH</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+AG%22">Carvalho AG</searchLink>; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lederman+HM%22">Lederman HM</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+ARC%22">Fernandes ARC</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Guimarães+JB%22">Guimarães JB</searchLink>; Department of Diagnostic Imaging, Federal University of São Paulo, 715 - Rua Napoleão de Barros, Hospital São Paulo, São Paulo, 04023-900, Brazil.; Department of Musculoskeletal Radiology, Fleury S.A. (Brazil), São Paulo, Brazil.; Department of Oncology, Support group for adolescents and children with cancer, São Paulo, Brazil.
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  Data: <searchLink fieldCode="JN" term="%220365332%22">Pediatric radiology</searchLink> [Pediatr Radiol] 2026 Jun; Vol. 56 (7), pp. 1572-1587. <i>Date of Electronic Publication: </i>2026 May 23.
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              Text: 2026 Jun
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