Aberrant activation of renal functional reserve and reduced tubule flow, but not obstruction, is associated with cystogenesis in Pkd2 mutant kidneys.

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Title: Aberrant activation of renal functional reserve and reduced tubule flow, but not obstruction, is associated with cystogenesis in Pkd2 mutant kidneys.
Authors: Thomas IN; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Rajendran S; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Li Z; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Haycraft CJ; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Croyle MJ; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States., Yoder BK; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Source: Function (Oxford, England) [Function (Oxf)] 2026 Jun 01; Vol. 7 (3), pp. e1142025. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101770668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2633-8823 (Electronic) Linking ISSN: 26338823 NLM ISO Abbreviation: Function (Oxf) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2633-8823
DOI:10.1152/function.114.2025