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Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells.

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Title: Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells.
Authors: Nathan N; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Paparoditis P; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Sarusi-Portuguez A; Mantoux Bioinformatics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Stoler-Barak L; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Horn HM; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Milo I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Mazor RD; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel., Levy-Barda A; Biobank, Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; Department of Digital Medical Technologies, Holon Institute of Technology, Holon, Israel., Yanichkin N; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel., Borcherding N; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA., Blecher-Gonen R; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Ronen R; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Nachman IB; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel., Goliand I; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Fellus-Alyagor L; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel., Salame TM; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Sagi I; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Siloni GH; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel., Gross M; Department of Otolaryngology-Head and Neck Surgery, Hadassah Medical Center, Jerusalem 9112102, Israel., Tenenbaum A; Department of Pediatrics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Kent I; Department of Surgery, Division of Colorectal Surgery, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Keren L; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Raban O; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Eitan R; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Shulman Z; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: ziv.shulman@weizmann.ac.il.
Source: Immunity [Immunity] 2026 Jun 09; Vol. 59 (6), pp. 1743-1757.e10. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
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  Data: Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells.
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  Data: <searchLink fieldCode="AU" term="%22Nathan+N%22">Nathan N</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Paparoditis+P%22">Paparoditis P</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Sarusi-Portuguez+A%22">Sarusi-Portuguez A</searchLink>; Mantoux Bioinformatics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Stoler-Barak+L%22">Stoler-Barak L</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Horn+HM%22">Horn HM</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Milo+I%22">Milo I</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Mazor+RD%22">Mazor RD</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Levy-Barda+A%22">Levy-Barda A</searchLink>; Biobank, Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; Department of Digital Medical Technologies, Holon Institute of Technology, Holon, Israel.<br /><searchLink fieldCode="AU" term="%22Yanichkin+N%22">Yanichkin N</searchLink>; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Borcherding+N%22">Borcherding N</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Blecher-Gonen+R%22">Blecher-Gonen R</searchLink>; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Ronen+R%22">Ronen R</searchLink>; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Nachman+IB%22">Nachman IB</searchLink>; The Crown Genomics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Goliand+I%22">Goliand I</searchLink>; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Fellus-Alyagor+L%22">Fellus-Alyagor L</searchLink>; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Salame+TM%22">Salame TM</searchLink>; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Sagi+I%22">Sagi I</searchLink>; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Siloni+GH%22">Siloni GH</searchLink>; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Gross+M%22">Gross M</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Hadassah Medical Center, Jerusalem 9112102, Israel.<br /><searchLink fieldCode="AU" term="%22Tenenbaum+A%22">Tenenbaum A</searchLink>; Department of Pediatrics, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Kent+I%22">Kent I</searchLink>; Department of Surgery, Division of Colorectal Surgery, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Keren+L%22">Keren L</searchLink>; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Raban+O%22">Raban O</searchLink>; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Eitan+R%22">Eitan R</searchLink>; Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Shulman+Z%22">Shulman Z</searchLink>; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: ziv.shulman@weizmann.ac.il.
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  Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2026 Jun 09; Vol. 59 (6), pp. 1743-1757.e10. <i>Date of Electronic Publication: </i>2026 May 26.
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