NOX4 signatures in human abdominal aortic aneurysm reveal links to vascular cell plasticity, extracellular matrix remodeling and inflammation.

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Title: NOX4 signatures in human abdominal aortic aneurysm reveal links to vascular cell plasticity, extracellular matrix remodeling and inflammation.
Authors: Sinha A; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Kapalla M; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schürmann C; Institute of Cardiovascular Physiology, Medical Faculty, Goethe University, Frankfurt am Main, Germany., Busch A; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Tabac R; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Mittag J; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Hamann B; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona, 17 08041, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain., Müglich M; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Kopaliani I; Department of Physiology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Poitz DM; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Jänichen C; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bundschuh RA; Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany; Institute of Radiopharmaceutical Cancer Research, Helmholtz Zentrum Dresden-Rossendorf (HZDR), Rossendorf, Germany., Klimova A; Institute for Medical Informatics and Biometry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Core Unit for Data Management and Analytics (CDMA), National Center for Tumor Diseases (NCT), Dresden, 01307, Germany., Reeps C; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schröder K; Institute of Cardiovascular Physiology, Medical Faculty, Goethe University, Frankfurt am Main, Germany; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Hofmann A; Division of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: anja.hofmann2@uniklinikum-dresden.de.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Sep; Vol. 253, pp. 320-333. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2026.05.299