Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.

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Title: Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.
Authors: Sun YY; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Lin HM; Department of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China., Ma J; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China., Xu ZJ; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Xue X; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China., Lu JJ; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wu JJ; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. wujiajia@shutcm.edu.cn.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China. wujiajia@shutcm.edu.cn., Hua XY; Department of Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. huaxuyun@shutcm.edu.cn., Zuo CT; Department of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China. zuochuantao@fudan.edu.cn., Xu JG; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xjg@shutcm.edu.cn.; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xjg@shutcm.edu.cn.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China. xjg@shutcm.edu.cn.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis
Database: MEDLINE Ultimate
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  Data: Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Sun+YY%22">Sun YY</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+HM%22">Lin HM</searchLink>; Department of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+ZJ%22">Xu ZJ</searchLink>; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lu+JJ%22">Lu JJ</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+JJ%22">Wu JJ</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. wujiajia@shutcm.edu.cn.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China. wujiajia@shutcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Hua+XY%22">Hua XY</searchLink>; Department of Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. huaxuyun@shutcm.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zuo+CT%22">Zuo CT</searchLink>; Department of Nuclear Medicine/PET center, Huashan Hospital, Fudan University, Shanghai, China. zuochuantao@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+JG%22">Xu JG</searchLink>; Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xjg@shutcm.edu.cn.; School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xjg@shutcm.edu.cn.; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China. xjg@shutcm.edu.cn.
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        Value: 10.1038/s41531-026-01409-5
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            – D: 26
              M: 05
              Text: 2026 May 26
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