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NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.

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Title: NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.
Authors: Nogués L; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. lnogues@cbm.csic.es.; Department of Molecular Biology, University Institute of Molecular Biology (IUBM-UAM), Centre for Molecular Biology 'Severo Ochoa' (CBMSO) UAM-CSIC, Autonomous University of Madrid, Madrid, Spain. lnogues@cbm.csic.es.; Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. lnogues@cbm.csic.es., Santos V; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., García-Agullo J; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., García-Silva S; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Melanoma Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Maiques O; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Hernández-Barranco A; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Department of Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Lausanne, Switzerland., Mazariegos MS; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Division of Pediatrics, Department of Clinical Sciences, Lund University, Lund, Sweden., Pérez-Martinez M; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Torres-Ruíz R; Molecular Cytogenetics Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Saltari A; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Turko P; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Mannino M; UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.; Dermatologia, Università Cattolica del Sacro Cuore, Rome, Italy., Nejatie A; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Nassour H; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Megías D; Advanced Optical Microscopy - ISCIII Madrid, Madrid, Spain., Peset I; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Blanco-Aparicio C; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Martínez S; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Levesque M; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Saragovi HU; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Sanz-Moreno V; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Peinado H; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. hector.peinado@cnb.csic.es.; Microenvironment and Metastasis Laboratory. Department of Immunology and Oncology, Centro Nacional de Biotecnología. Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain. hector.peinado@cnb.csic.es.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (14), pp. 4988-5023. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-026-00803-2