View in EDS HTML Full Text PDF Full Text

NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.

Saved in:
Bibliographic Details
Title: NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.
Authors: Nogués L; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. lnogues@cbm.csic.es.; Department of Molecular Biology, University Institute of Molecular Biology (IUBM-UAM), Centre for Molecular Biology 'Severo Ochoa' (CBMSO) UAM-CSIC, Autonomous University of Madrid, Madrid, Spain. lnogues@cbm.csic.es.; Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. lnogues@cbm.csic.es., Santos V; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., García-Agullo J; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., García-Silva S; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Melanoma Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Maiques O; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK., Hernández-Barranco A; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Department of Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Lausanne, Switzerland., Mazariegos MS; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Division of Pediatrics, Department of Clinical Sciences, Lund University, Lund, Sweden., Pérez-Martinez M; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Torres-Ruíz R; Molecular Cytogenetics Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Saltari A; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Turko P; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Mannino M; UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.; Dermatologia, Università Cattolica del Sacro Cuore, Rome, Italy., Nejatie A; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Nassour H; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Megías D; Advanced Optical Microscopy - ISCIII Madrid, Madrid, Spain., Peset I; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Blanco-Aparicio C; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Martínez S; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Levesque M; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland., Saragovi HU; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada., Sanz-Moreno V; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK., Peinado H; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. hector.peinado@cnb.csic.es.; Microenvironment and Metastasis Laboratory. Department of Immunology and Oncology, Centro Nacional de Biotecnología. Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain. hector.peinado@cnb.csic.es.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (14), pp. 4988-5023. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42192125
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Nogués+L%22">Nogués L</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. lnogues@cbm.csic.es.; Department of Molecular Biology, University Institute of Molecular Biology (IUBM-UAM), Centre for Molecular Biology 'Severo Ochoa' (CBMSO) UAM-CSIC, Autonomous University of Madrid, Madrid, Spain. lnogues@cbm.csic.es.; Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. lnogues@cbm.csic.es.<br /><searchLink fieldCode="AU" term="%22Santos+V%22">Santos V</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Agullo+J%22">García-Agullo J</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García-Silva+S%22">García-Silva S</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Melanoma Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Maiques+O%22">Maiques O</searchLink>; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.; Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hernández-Barranco+A%22">Hernández-Barranco A</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Department of Oncology, University of Lausanne, Ludwig Institute for Cancer Research, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mazariegos+MS%22">Mazariegos MS</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain.; Division of Pediatrics, Department of Clinical Sciences, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Pérez-Martinez+M%22">Pérez-Martinez M</searchLink>; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Torres-Ruíz+R%22">Torres-Ruíz R</searchLink>; Molecular Cytogenetics Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Saltari+A%22">Saltari A</searchLink>; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Turko+P%22">Turko P</searchLink>; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mannino+M%22">Mannino M</searchLink>; UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.; Dermatologia, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nejatie+A%22">Nejatie A</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Nassour+H%22">Nassour H</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Megías+D%22">Megías D</searchLink>; Advanced Optical Microscopy - ISCIII Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Peset+I%22">Peset I</searchLink>; Cofocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Blanco-Aparicio+C%22">Blanco-Aparicio C</searchLink>; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+S%22">Martínez S</searchLink>; Experimental Therapeutics Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Levesque+M%22">Levesque M</searchLink>; Department of Dermatology, University of Zurich, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Saragovi+HU%22">Saragovi HU</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec, Canada.; Centre for Translational Research in Cancer-Jewish General Hospital-Lady Davis Institute, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Sanz-Moreno+V%22">Sanz-Moreno V</searchLink>; Cytoskeleton and Cancer Metastasis Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Peinado+H%22">Peinado H</searchLink>; Microenvironment and Metastasis Laboratory, Department of Tumor Biology, Spanish National Cancer Research Center (CNIO), Madrid, Spain. hector.peinado@cnb.csic.es.; Microenvironment and Metastasis Laboratory. Department of Immunology and Oncology, Centro Nacional de Biotecnología. Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain. hector.peinado@cnb.csic.es.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Jul; Vol. 45 (14), pp. 4988-5023. <i>Date of Electronic Publication: </i>2026 May 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8208664 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1460-2075 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202614189%22">02614189 </searchLink><i>NLM ISO Abbreviation: </i>EMBO J <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42192125
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s44318-026-00803-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 4988
    Titles:
      – TitleFull: NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nogués L
      – PersonEntity:
          Name:
            NameFull: Santos V
      – PersonEntity:
          Name:
            NameFull: García-Agullo J
      – PersonEntity:
          Name:
            NameFull: García-Silva S
      – PersonEntity:
          Name:
            NameFull: Maiques O
      – PersonEntity:
          Name:
            NameFull: Hernández-Barranco A
      – PersonEntity:
          Name:
            NameFull: Mazariegos MS
      – PersonEntity:
          Name:
            NameFull: Pérez-Martinez M
      – PersonEntity:
          Name:
            NameFull: Torres-Ruíz R
      – PersonEntity:
          Name:
            NameFull: Saltari A
      – PersonEntity:
          Name:
            NameFull: Turko P
      – PersonEntity:
          Name:
            NameFull: Mannino M
      – PersonEntity:
          Name:
            NameFull: Nejatie A
      – PersonEntity:
          Name:
            NameFull: Nassour H
      – PersonEntity:
          Name:
            NameFull: Megías D
      – PersonEntity:
          Name:
            NameFull: Peset I
      – PersonEntity:
          Name:
            NameFull: Blanco-Aparicio C
      – PersonEntity:
          Name:
            NameFull: Martínez S
      – PersonEntity:
          Name:
            NameFull: Levesque M
      – PersonEntity:
          Name:
            NameFull: Saragovi HU
      – PersonEntity:
          Name:
            NameFull: Sanz-Moreno V
      – PersonEntity:
          Name:
            NameFull: Peinado H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1460-2075
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 14
          Titles:
            – TitleFull: The EMBO journal
              Type: main
ResultId 1