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Vutrisiran-Mediated Knockdown of Transthyretin in Patients with ATTR Amyloidosis.

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Title: Vutrisiran-Mediated Knockdown of Transthyretin in Patients with ATTR Amyloidosis.
Authors: Fontana M; National Amyloidosis Centre, UCL, Division of Medicine, University College London, Royal Free Hospital, Pond Street, London, NW3 2QG, UK. marianna.fontana@nhs.net., Algalarrondo V; French Reference Centre for Cardiac Amyloidosis Ceramic-Cardio, Department of Cardiology, Bichat University Hospital, AP-HP, Paris, France., Garcia-Pavia P; Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Maurer MS; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Gillmore JD; National Amyloidosis Centre, UCL, Division of Medicine, University College London, Royal Free Hospital, Pond Street, London, NW3 2QG, UK., Cappelli F; Tuscan Regional Amyloidosis Centre and Cardiomyopathy Unit, Careggi University Hospital, University of Florence, Florence, Italy., Kolachana K; Alnylam Pharmaceuticals, Cambridge, MA, USA., Gao X; Alnylam Pharmaceuticals, Cambridge, MA, USA., Jadhav S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Mehrotra N; Alnylam Pharmaceuticals, Cambridge, MA, USA., Robbie G; Alnylam Pharmaceuticals, Cambridge, MA, USA., Badri P; Alnylam Pharmaceuticals, Cambridge, MA, USA.
Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 Jul; Vol. 65 (7), pp. 1073-1085. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vutrisiran-Mediated Knockdown of Transthyretin in Patients with ATTR Amyloidosis.
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  Data: <searchLink fieldCode="AU" term="%22Fontana+M%22">Fontana M</searchLink>; National Amyloidosis Centre, UCL, Division of Medicine, University College London, Royal Free Hospital, Pond Street, London, NW3 2QG, UK. marianna.fontana@nhs.net.<br /><searchLink fieldCode="AU" term="%22Algalarrondo+V%22">Algalarrondo V</searchLink>; French Reference Centre for Cardiac Amyloidosis Ceramic-Cardio, Department of Cardiology, Bichat University Hospital, AP-HP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Garcia-Pavia+P%22">Garcia-Pavia P</searchLink>; Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, and Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Maurer+MS%22">Maurer MS</searchLink>; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gillmore+JD%22">Gillmore JD</searchLink>; National Amyloidosis Centre, UCL, Division of Medicine, University College London, Royal Free Hospital, Pond Street, London, NW3 2QG, UK.<br /><searchLink fieldCode="AU" term="%22Cappelli+F%22">Cappelli F</searchLink>; Tuscan Regional Amyloidosis Centre and Cardiomyopathy Unit, Careggi University Hospital, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Kolachana+K%22">Kolachana K</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+S%22">Jadhav S</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mehrotra+N%22">Mehrotra N</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Robbie+G%22">Robbie G</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Badri+P%22">Badri P</searchLink>; Alnylam Pharmaceuticals, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%227606849%22">Clinical pharmacokinetics</searchLink> [Clin Pharmacokinet] 2026 Jul; Vol. 65 (7), pp. 1073-1085. <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22%22"> </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>7606849 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1926 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203125963%22">03125963 </searchLink><i>NLM ISO Abbreviation: </i>Clin Pharmacokinet <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul
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