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Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.

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Title: Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.
Authors: Koh TY; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Cho WR; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Jeon HY; Scripps Korea Antibody Institute, Kangwon National University Chuncheon Campus, Chuncheon, Kangwon-do, 24341, South Korea., Moon CH; Biomedical Research Institute, Kangwon National University Hospital, Chuncheon, Kangwon-do, 24289, South Korea., Yoon JS; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Kim M; Department of Anesthesiology, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Ha KS; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea. Electronic address: ksha@kangwon.ac.kr.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Sep; Vol. 253, pp. 208-220. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2026.05.327