Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.

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Title: Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.
Authors: Koh TY; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Cho WR; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Jeon HY; Scripps Korea Antibody Institute, Kangwon National University Chuncheon Campus, Chuncheon, Kangwon-do, 24341, South Korea., Moon CH; Biomedical Research Institute, Kangwon National University Hospital, Chuncheon, Kangwon-do, 24289, South Korea., Yoon JS; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Kim M; Department of Anesthesiology, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea., Ha KS; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea. Electronic address: ksha@kangwon.ac.kr.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Sep; Vol. 253, pp. 208-220. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Koh+TY%22">Koh TY</searchLink>; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea.<br /><searchLink fieldCode="AU" term="%22Cho+WR%22">Cho WR</searchLink>; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+HY%22">Jeon HY</searchLink>; Scripps Korea Antibody Institute, Kangwon National University Chuncheon Campus, Chuncheon, Kangwon-do, 24341, South Korea.<br /><searchLink fieldCode="AU" term="%22Moon+CH%22">Moon CH</searchLink>; Biomedical Research Institute, Kangwon National University Hospital, Chuncheon, Kangwon-do, 24289, South Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+JS%22">Yoon JS</searchLink>; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Anesthesiology, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea.<br /><searchLink fieldCode="AU" term="%22Ha+KS%22">Ha KS</searchLink>; Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon-do, 24341, South Korea. Electronic address: ksha@kangwon.ac.kr.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 Sep; Vol. 253, pp. 208-220. <i>Date of Electronic Publication: </i>2026 May 26.
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      – Type: doi
        Value: 10.1016/j.freeradbiomed.2026.05.327
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        Text: English
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        StartPage: 208
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      – TitleFull: Sustained human C-peptide protects against retinal neurodegeneration via PEDF restoration and oxidative stress inhibition in a mouse model of age-related macular degeneration.
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            NameFull: Cho WR
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              Text: 2026 Sep
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              Y: 2026
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