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Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections.

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Title: Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections.
Authors: Zakrzewski P; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Rice CM; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Naveh C; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Dowell I; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Fleming K; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Ramesh AV; Bristol Veterinary School, University of Bristol, Bristol, UK., Jones R; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Moura PL; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden., Cela D; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Groves S; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Fletcher-Jones S; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Victory Y; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Bhima M; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Ebmeier S; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Carey L; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Butler M; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Satchell SC; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Berg A; Department of Medicine, Stavanger University Hospital, Stavanger, Norway.; Department of Medicine, Central Hospital of Maputo, Maputo, Mozambique., Palolite N; Department of Medicine, Central Hospital of Maputo, Maputo, Mozambique., Nyirenda J; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Nyasulu W; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Zgambo I; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Attipa C; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Wooldridge L; Bristol Veterinary School, University of Bristol, Bristol, UK., Davidson AD; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK., Cunnington A; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK., Moxon CA; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Amulic B; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. borko.amulic@bristol.ac.uk.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul; Vol. 18 (7), pp. 2691-2722. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections.
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  Data: <searchLink fieldCode="AU" term="%22Zakrzewski+P%22">Zakrzewski P</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Rice+CM%22">Rice CM</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Naveh+C%22">Naveh C</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Dowell+I%22">Dowell I</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Fleming+K%22">Fleming K</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Ramesh+AV%22">Ramesh AV</searchLink>; Bristol Veterinary School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Jones+R%22">Jones R</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Moura+PL%22">Moura PL</searchLink>; Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Cela+D%22">Cela D</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Groves+S%22">Groves S</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Fletcher-Jones+S%22">Fletcher-Jones S</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Victory+Y%22">Victory Y</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Bhima+M%22">Bhima M</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Ebmeier+S%22">Ebmeier S</searchLink>; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Carey+L%22">Carey L</searchLink>; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Butler+M%22">Butler M</searchLink>; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Satchell+SC%22">Satchell SC</searchLink>; Bristol Medical School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Berg+A%22">Berg A</searchLink>; Department of Medicine, Stavanger University Hospital, Stavanger, Norway.; Department of Medicine, Central Hospital of Maputo, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Palolite+N%22">Palolite N</searchLink>; Department of Medicine, Central Hospital of Maputo, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Nyirenda+J%22">Nyirenda J</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Nyasulu+W%22">Nyasulu W</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Zgambo+I%22">Zgambo I</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Attipa+C%22">Attipa C</searchLink>; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wooldridge+L%22">Wooldridge L</searchLink>; Bristol Veterinary School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Davidson+AD%22">Davidson AD</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Cunnington+A%22">Cunnington A</searchLink>; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Moxon+CA%22">Moxon CA</searchLink>; Malawi-Liverpool Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.; School of Infection and Immunity, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Amulic+B%22">Amulic B</searchLink>; School of Cellular and Molecular Medicine, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. borko.amulic@bristol.ac.uk.
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