Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.
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| Title: | Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription. |
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| Authors: | Wang SC; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Hsieh CC; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan., Yuan TC; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Lin SM; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Chen CW; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Chang CC; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan., Huang SC; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Wang EC; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Huang YJ; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Chiang MH; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan., Horng YC; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Hou MH; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2026 May 20; Vol. 54 (10). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkag520 |
