View in EDS HTML Full Text PDF Full Text

Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.

Saved in:
Bibliographic Details
Title: Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.
Authors: Wang SC; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Hsieh CC; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan., Yuan TC; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Lin SM; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Chen CW; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Chang CC; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan., Huang SC; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan., Wang EC; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Huang YJ; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Chiang MH; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan., Horng YC; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan., Hou MH; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan.
Source: Nucleic acids research [Nucleic Acids Res] 2026 May 20; Vol. 54 (10).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42206361
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wang+SC%22">Wang SC</searchLink>; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+CC%22">Hsieh CC</searchLink>; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yuan+TC%22">Yuan TC</searchLink>; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SM%22">Lin SM</searchLink>; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CW%22">Chen CW</searchLink>; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SC%22">Huang SC</searchLink>; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+EC%22">Wang EC</searchLink>; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YJ%22">Huang YJ</searchLink>; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+MH%22">Chiang MH</searchLink>; Institute of Chemistry, Academia Sinica, Taipei 11528, Taiwan.<br /><searchLink fieldCode="AU" term="%22Horng+YC%22">Horng YC</searchLink>; Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+MH%22">Hou MH</searchLink>; Doctoral Program in Medical Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.; Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220411011%22">Nucleic acids research</searchLink> [Nucleic Acids Res] 2026 May 20; Vol. 54 (10).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42206361
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/nar/gkag520
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wang SC
      – PersonEntity:
          Name:
            NameFull: Hsieh CC
      – PersonEntity:
          Name:
            NameFull: Yuan TC
      – PersonEntity:
          Name:
            NameFull: Lin SM
      – PersonEntity:
          Name:
            NameFull: Chen CW
      – PersonEntity:
          Name:
            NameFull: Chang CC
      – PersonEntity:
          Name:
            NameFull: Huang SC
      – PersonEntity:
          Name:
            NameFull: Wang EC
      – PersonEntity:
          Name:
            NameFull: Huang YJ
      – PersonEntity:
          Name:
            NameFull: Chiang MH
      – PersonEntity:
          Name:
            NameFull: Horng YC
      – PersonEntity:
          Name:
            NameFull: Hou MH
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 20
              M: 05
              Text: 2026 May 20
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1362-4962
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Nucleic acids research
              Type: main
ResultId 1