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CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice.

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Title: CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice.
Authors: Zhou J; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Wang C; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China., Wu Y; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China., Zhao B; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China., Yang Y; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China., Ye T; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang K; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China., Li F; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China., Hu J; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China., Zhang K; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China., Liu F; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China., Wang W; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230027, China., Wang C; Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, 441021, China., Wang Z; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China. wangzf@sustech.edu.cn.; Department of System Biology, School of Life Science, Southern University of Science and Technology, Shenzhen, China. wangzf@sustech.edu.cn., Chuai X; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China. chuaixia@wh.iov.cn., Chiu S; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China. qiux@ustc.edu.cn.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230027, China. qiux@ustc.edu.cn.; Department of Laboratory Medicine, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, 230031, China. qiux@ustc.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2026 May 28; Vol. 7 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China.<br /><searchLink fieldCode="AU" term="%22Ye+T%22">Ye T</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230027, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, 441021, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Research and Development Department, Shanghai CirCode Biomedicine Co.Ltd, Shanghai, 200131, China. wangzf@sustech.edu.cn.; Department of System Biology, School of Life Science, Southern University of Science and Technology, Shenzhen, China. wangzf@sustech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chuai+X%22">Chuai X</searchLink>; State Key Laboratory of Virology and Biosafety, Center for Biosafety Mega Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430207, China. chuaixia@wh.iov.cn.<br /><searchLink fieldCode="AU" term="%22Chiu+S%22">Chiu S</searchLink>; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230027, China. qiux@ustc.edu.cn.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui, 230027, China. qiux@ustc.edu.cn.; Department of Laboratory Medicine, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, 230031, China. qiux@ustc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 May 28; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 May 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42207442
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        Value: 10.1186/s43556-026-00474-9
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        Text: English
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      – TitleFull: CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice.
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