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Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.

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Title: Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.
Authors: Vincze K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. katalin.vincze@ki.se., Szwajda A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Ploner A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Kang X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Tang B; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden., Qin C; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Domenighetti C; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Sugier PE; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Ashok Kumar Sreelatha A; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany., Schulte C; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Portugal B; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., May P; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg., Bobbili DR; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg., Radivojkov-Blagojevic M; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany., Lichtner P; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany., Singleton AB; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.; National Institutes of Health, Center For Alzheimer's and Related Dementias, Bethesda, MD, USA., Hernandez DG; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA., Edsall C; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA., Mellick GD; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia., Zimprich A; Department of Neurology, Medical University of Vienna, Vienna, Austria., Pirker W; Department of Neurology, Klinik Ottakring, Vienna, Austria., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Lang AE; Toronto Western Hospital, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto, ON, Canada.; Division of Neurology, University of Toronto, Toronto, ON, Canada., Koks S; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia., Taba P; Institute of Clinical Medicine, University of Tartu, Faculty of Medicine, Tartu, Estonia.; Clinic of Neurology, Tartu University Hospital, Tartu, Estonia., Lesage S; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France., Brice A; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France., Corvol JC; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.; Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, Paris, France., Chartier-Harlin MC; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France., Mutez E; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France., Brockmann K; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Deutschlander AB; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany., Burbulla LF; Metabolic Biochemistry, Ludwig-Maximilians-Universität München, Faculty of Medicine, Biomedical Center, Munich, Germany., Hadjigeorgiou GM; Department of Neurology, University of Cyprus, Medical School, Nicosia, Cyprus.; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece., Dardiotis E; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece., Stefanis L; Biomedical Research Foundation of the Academy of Athens, Experimental Surgery and Translational Research, Center of Clinical Research, Athens, Greece.; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece., Simitsi AM; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece., Valente EM; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Mondino Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy., Petrucci S; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.; UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy., Straniero L; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Zecchinelli A; Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Parkinson Institute, Milan, Italy., Pezzoli G; Fontazione Grigioni, Parkinson Institute, Milan, Italy., Brighina L; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Ferrarese C; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Annesi G; National Research Council, Cosenza, Italy., Quattrone A; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy., Gagliardi M; Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy., Matsuo H; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan., Nakayama A; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan., Hattori N; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan., Nishioka K; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan., Chung SJ; Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea., Kim YJ; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea., Kolber P; Centre Hospitalier de Luxembourg, Neurology, Luxembourg, Luxembourg., Van de Warrenburg BP; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands., Bloem BR; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands., Toft M; Department of Neurology, Oslo University Hospital, Oslo, Norway., Pihlstrøm L; Department of Neurology, Oslo University Hospital, Oslo, Norway., Correia Guedes L; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Department of Neurosciences and Mental Health, Neurology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal., Ferreira JJ; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Laboratory of Clinical Pharmacology and Therapeutics, University of Lisbon, Faculty of Medicine, Lisbon, Portugal., Bardien S; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics,Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa., Carr J; Department of Medicine, Division of Neurology, Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch, South Africa., Tolosa E; Parkinson's disease & Movement Disorders Unit, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Neurology Service, Barcelona, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas, Barcelona, Spain., Ezquerra M; Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, University of Barcelona, Institut de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.; Department of Neurology, Movement Disorders Unit, University Hospital Mútua de Terrassa, Terrassa, Spain., Ran C; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Belin AC; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Puschmann A; Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund, Sweden., Clarke CE; University of Birmingham, Birmingham, United Kingdom.; Sandwell & West Birmingham Hospitals NHS Trust, West Bromwich, United Kingdom., Morrison KE; Health and Life Sciences, Faculty of Medicine, Queens University, Belfast, United Kingdom., Tan M; Department of Clinical and Movement Neurosciences, University College London, UCL Queen Square Institute of Neurology, London, United Kingdom., Krainc D; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Farrer MJ; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Landoulsi Z; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg., Kruger R; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg., Gasser T; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Elbaz A; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Sharma M; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Carlsson S; Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Wirdefeldt K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Domenighetti C; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Sugier PE; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Ashok Kumar Sreelatha A; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany., Schulte C; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Portugal B; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., May P; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg., Bobbili DR; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg., Radivojkov-Blagojevic M; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany., Lichtner P; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany., Singleton AB; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.; National Institutes of Health, Center For Alzheimer's and Related Dementias, Bethesda, MD, USA., Hernandez DG; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA., Edsall C; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA., Mellick GD; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia., Zimprich A; Department of Neurology, Medical University of Vienna, Vienna, Austria., Pirker W; Department of Neurology, Klinik Ottakring, Vienna, Austria., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Lang AE; Toronto Western Hospital, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto, ON, Canada.; Division of Neurology, University of Toronto, Toronto, ON, Canada., Koks S; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia., Taba P; Institute of Clinical Medicine, University of Tartu, Faculty of Medicine, Tartu, Estonia.; Clinic of Neurology, Tartu University Hospital, Tartu, Estonia., Lesage S; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France., Brice A; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France., Corvol JC; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.; Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, Paris, France., Chartier-Harlin MC; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France., Mutez E; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France., Brockmann K; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Deutschlander AB; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany., Burbulla LF; Metabolic Biochemistry, Ludwig-Maximilians-Universität München, Faculty of Medicine, Biomedical Center, Munich, Germany., Hadjigeorgiou GM; Department of Neurology, University of Cyprus, Medical School, Nicosia, Cyprus.; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece., Dardiotis E; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece., Stefanis L; Biomedical Research Foundation of the Academy of Athens, Experimental Surgery and Translational Research, Center of Clinical Research, Athens, Greece.; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece., Simitsi AM; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece., Valente EM; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Mondino Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy., Petrucci S; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.; UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy., Straniero L; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Zecchinelli A; Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Parkinson Institute, Milan, Italy., Pezzoli G; Fontazione Grigioni, Parkinson Institute, Milan, Italy., Brighina L; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Ferrarese C; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Annesi G; National Research Council, Cosenza, Italy., Quattrone A; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy., Gagliardi M; Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy., Matsuo H; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan., Nakayama A; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan., Hattori N; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan., Nishioka K; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan., Chung SJ; Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea., Kim YJ; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea., Kolber P; Centre Hospitalier de Luxembourg, Neurology, Luxembourg, Luxembourg., Van de Warrenburg BP; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands., Bloem BR; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands., Toft M; Department of Neurology, Oslo University Hospital, Oslo, Norway., Pihlstrøm L; Department of Neurology, Oslo University Hospital, Oslo, Norway., Correia Guedes L; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Department of Neurosciences and Mental Health, Neurology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal., Ferreira JJ; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Laboratory of Clinical Pharmacology and Therapeutics, University of Lisbon, Faculty of Medicine, Lisbon, Portugal., Bardien S; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics,Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa., Carr J; Department of Medicine, Division of Neurology, Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch, South Africa., Tolosa E; Parkinson's disease & Movement Disorders Unit, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Neurology Service, Barcelona, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas, Barcelona, Spain., Ezquerra M; Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, University of Barcelona, Institut de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.; Department of Neurology, Movement Disorders Unit, University Hospital Mútua de Terrassa, Terrassa, Spain., Ran C; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Belin AC; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Puschmann A; Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund, Sweden., Clarke CE; University of Birmingham, Birmingham, United Kingdom.; Sandwell & West Birmingham Hospitals NHS Trust, West Bromwich, United Kingdom., Morrison KE; Health and Life Sciences, Faculty of Medicine, Queens University, Belfast, United Kingdom., Tan M; Department of Clinical and Movement Neurosciences, University College London, UCL Queen Square Institute of Neurology, London, United Kingdom., Krainc D; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Farrer MJ; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Landoulsi Z; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg., Kruger R; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg., Gasser T; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany., Elbaz A; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France., Sharma M; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany., Wirdefeldt K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Corporate Authors: Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) Consortium
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 May 28; Vol. 12 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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Items – Name: Title
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  Data: Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Vincze+K%22">Vincze K</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. katalin.vincze@ki.se.<br /><searchLink fieldCode="AU" term="%22Szwajda+A%22">Szwajda A</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Ploner+A%22">Ploner A</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Karlsson+R%22">Karlsson R</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kang+X%22">Kang X</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Tang+B%22">Tang B</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Qin+C%22">Qin C</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Domenighetti+C%22">Domenighetti C</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Sugier+PE%22">Sugier PE</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ashok+Kumar+Sreelatha+A%22">Ashok Kumar Sreelatha A</searchLink>; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+C%22">Schulte C</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Portugal+B%22">Portugal B</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22May+P%22">May P</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Bobbili+DR%22">Bobbili DR</searchLink>; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Radivojkov-Blagojevic+M%22">Radivojkov-Blagojevic M</searchLink>; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lichtner+P%22">Lichtner P</searchLink>; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.; National Institutes of Health, Center For Alzheimer's and Related Dementias, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+DG%22">Hernandez DG</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Edsall+C%22">Edsall C</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mellick+GD%22">Mellick GD</searchLink>; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Zimprich+A%22">Zimprich A</searchLink>; Department of Neurology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pirker+W%22">Pirker W</searchLink>; Department of Neurology, Klinik Ottakring, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rogaeva+E%22">Rogaeva E</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lang+AE%22">Lang AE</searchLink>; Toronto Western Hospital, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto, ON, Canada.; Division of Neurology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Koks+S%22">Koks S</searchLink>; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Taba+P%22">Taba P</searchLink>; Institute of Clinical Medicine, University of Tartu, Faculty of Medicine, Tartu, Estonia.; Clinic of Neurology, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Lesage+S%22">Lesage S</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brice+A%22">Brice A</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Corvol+JC%22">Corvol JC</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.; Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chartier-Harlin+MC%22">Chartier-Harlin MC</searchLink>; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France.<br /><searchLink fieldCode="AU" term="%22Mutez+E%22">Mutez E</searchLink>; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France.<br /><searchLink fieldCode="AU" term="%22Brockmann+K%22">Brockmann K</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Deutschlander+AB%22">Deutschlander AB</searchLink>; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Burbulla+LF%22">Burbulla LF</searchLink>; Metabolic Biochemistry, Ludwig-Maximilians-Universität München, Faculty of Medicine, Biomedical Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hadjigeorgiou+GM%22">Hadjigeorgiou GM</searchLink>; Department of Neurology, University of Cyprus, Medical School, Nicosia, Cyprus.; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Dardiotis+E%22">Dardiotis E</searchLink>; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Stefanis+L%22">Stefanis L</searchLink>; Biomedical Research Foundation of the Academy of Athens, Experimental Surgery and Translational Research, Center of Clinical Research, Athens, Greece.; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Simitsi+AM%22">Simitsi AM</searchLink>; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Valente+EM%22">Valente EM</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Mondino Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Petrucci+S%22">Petrucci S</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.; UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Straniero+L%22">Straniero L</searchLink>; Department of Biomedical Sciences, Humanitas University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zecchinelli+A%22">Zecchinelli A</searchLink>; Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Parkinson Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pezzoli+G%22">Pezzoli G</searchLink>; Fontazione Grigioni, Parkinson Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brighina+L%22">Brighina L</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrarese+C%22">Ferrarese C</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Annesi+G%22">Annesi G</searchLink>; National Research Council, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Quattrone+A%22">Quattrone A</searchLink>; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Gagliardi+M%22">Gagliardi M</searchLink>; Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Matsuo+H%22">Matsuo H</searchLink>; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+A%22">Nakayama A</searchLink>; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Hattori+N%22">Hattori N</searchLink>; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishioka+K%22">Nishioka K</searchLink>; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Chung+SJ%22">Chung SJ</searchLink>; Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kolber+P%22">Kolber P</searchLink>; Centre Hospitalier de Luxembourg, Neurology, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Van+de+Warrenburg+BP%22">Van de Warrenburg BP</searchLink>; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bloem+BR%22">Bloem BR</searchLink>; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Toft+M%22">Toft M</searchLink>; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Pihlstrøm+L%22">Pihlstrøm L</searchLink>; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Correia+Guedes+L%22">Correia Guedes L</searchLink>; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Department of Neurosciences and Mental Health, Neurology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Ferreira+JJ%22">Ferreira JJ</searchLink>; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Laboratory of Clinical Pharmacology and Therapeutics, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Bardien+S%22">Bardien S</searchLink>; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics,Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Carr+J%22">Carr J</searchLink>; Department of Medicine, Division of Neurology, Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Tolosa+E%22">Tolosa E</searchLink>; Parkinson's disease & Movement Disorders Unit, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Neurology Service, Barcelona, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ezquerra+M%22">Ezquerra M</searchLink>; Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, University of Barcelona, Institut de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor+P%22">Pastor P</searchLink>; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.; Department of Neurology, Movement Disorders Unit, University Hospital Mútua de Terrassa, Terrassa, Spain.<br /><searchLink fieldCode="AU" term="%22Ran+C%22">Ran C</searchLink>; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Belin+AC%22">Belin AC</searchLink>; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Puschmann+A%22">Puschmann A</searchLink>; Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Clarke+CE%22">Clarke CE</searchLink>; University of Birmingham, Birmingham, United Kingdom.; Sandwell & West Birmingham Hospitals NHS Trust, West Bromwich, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morrison+KE%22">Morrison KE</searchLink>; Health and Life Sciences, Faculty of Medicine, Queens University, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tan+M%22">Tan M</searchLink>; Department of Clinical and Movement Neurosciences, University College London, UCL Queen Square Institute of Neurology, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Krainc+D%22">Krainc D</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Farrer+MJ%22">Farrer MJ</searchLink>; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Landoulsi+Z%22">Landoulsi Z</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Kruger+R%22">Kruger R</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Gasser+T%22">Gasser T</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Elbaz+A%22">Elbaz A</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pedersen+NL%22">Pedersen NL</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Carlsson+S%22">Carlsson S</searchLink>; Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hägg+S%22">Hägg S</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Wirdefeldt+K%22">Wirdefeldt K</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Domenighetti+C%22">Domenighetti C</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Sugier+PE%22">Sugier PE</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ashok+Kumar+Sreelatha+A%22">Ashok Kumar Sreelatha A</searchLink>; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+C%22">Schulte C</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Portugal+B%22">Portugal B</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22May+P%22">May P</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Bobbili+DR%22">Bobbili DR</searchLink>; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Radivojkov-Blagojevic+M%22">Radivojkov-Blagojevic M</searchLink>; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lichtner+P%22">Lichtner P</searchLink>; Helmholtz Zentrum München, Institute of Human Genetics, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.; National Institutes of Health, Center For Alzheimer's and Related Dementias, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+DG%22">Hernandez DG</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Edsall+C%22">Edsall C</searchLink>; National Institutes of Health, Laboratory of Neurogenetics, Molecular Genetics Section, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mellick+GD%22">Mellick GD</searchLink>; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Zimprich+A%22">Zimprich A</searchLink>; Department of Neurology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pirker+W%22">Pirker W</searchLink>; Department of Neurology, Klinik Ottakring, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rogaeva+E%22">Rogaeva E</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lang+AE%22">Lang AE</searchLink>; Toronto Western Hospital, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto, ON, Canada.; Division of Neurology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Koks+S%22">Koks S</searchLink>; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Taba+P%22">Taba P</searchLink>; Institute of Clinical Medicine, University of Tartu, Faculty of Medicine, Tartu, Estonia.; Clinic of Neurology, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Lesage+S%22">Lesage S</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brice+A%22">Brice A</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Corvol+JC%22">Corvol JC</searchLink>; Department of Neurologie, Sorbonne University, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.; Assistance Publique Hôpitaux de Paris, Department of Neurology, CIC Neurosciences, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chartier-Harlin+MC%22">Chartier-Harlin MC</searchLink>; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France.<br /><searchLink fieldCode="AU" term="%22Mutez+E%22">Mutez E</searchLink>; Centre de Recherche Lille Neurosciences & Cognition, University of Lille, Inserm, Lille, France.<br /><searchLink fieldCode="AU" term="%22Brockmann+K%22">Brockmann K</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Deutschlander+AB%22">Deutschlander AB</searchLink>; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Neurology, Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Burbulla+LF%22">Burbulla LF</searchLink>; Metabolic Biochemistry, Ludwig-Maximilians-Universität München, Faculty of Medicine, Biomedical Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hadjigeorgiou+GM%22">Hadjigeorgiou GM</searchLink>; Department of Neurology, University of Cyprus, Medical School, Nicosia, Cyprus.; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Dardiotis+E%22">Dardiotis E</searchLink>; Laboratory of Neurogenetics, University Hospital of Larissa, University of Thessaly, Department of Neurology, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Stefanis+L%22">Stefanis L</searchLink>; Biomedical Research Foundation of the Academy of Athens, Experimental Surgery and Translational Research, Center of Clinical Research, Athens, Greece.; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Simitsi+AM%22">Simitsi AM</searchLink>; 1st Department of Neurology, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Valente+EM%22">Valente EM</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Mondino Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Petrucci+S%22">Petrucci S</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.; UOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Straniero+L%22">Straniero L</searchLink>; Department of Biomedical Sciences, Humanitas University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zecchinelli+A%22">Zecchinelli A</searchLink>; Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Parkinson Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pezzoli+G%22">Pezzoli G</searchLink>; Fontazione Grigioni, Parkinson Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Brighina+L%22">Brighina L</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrarese+C%22">Ferrarese C</searchLink>; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery and Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Annesi+G%22">Annesi G</searchLink>; National Research Council, Cosenza, Italy.<br /><searchLink fieldCode="AU" term="%22Quattrone+A%22">Quattrone A</searchLink>; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Gagliardi+M%22">Gagliardi M</searchLink>; Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Matsuo+H%22">Matsuo H</searchLink>; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakayama+A%22">Nakayama A</searchLink>; Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Hattori+N%22">Hattori N</searchLink>; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishioka+K%22">Nishioka K</searchLink>; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Chung+SJ%22">Chung SJ</searchLink>; Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kolber+P%22">Kolber P</searchLink>; Centre Hospitalier de Luxembourg, Neurology, Luxembourg, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Van+de+Warrenburg+BP%22">Van de Warrenburg BP</searchLink>; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bloem+BR%22">Bloem BR</searchLink>; Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Toft+M%22">Toft M</searchLink>; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Pihlstrøm+L%22">Pihlstrøm L</searchLink>; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Correia+Guedes+L%22">Correia Guedes L</searchLink>; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Department of Neurosciences and Mental Health, Neurology, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Ferreira+JJ%22">Ferreira JJ</searchLink>; Instituto de Medicina Molecular João Lobo Antunes, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.; Laboratory of Clinical Pharmacology and Therapeutics, University of Lisbon, Faculty of Medicine, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Bardien+S%22">Bardien S</searchLink>; Department of Biomedical Sciences, Division of Molecular Biology and Human Genetics,Stellenbosch University, Faculty of Medicine and Health Sciences, Cape Town, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Carr+J%22">Carr J</searchLink>; Department of Medicine, Division of Neurology, Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Tolosa+E%22">Tolosa E</searchLink>; Parkinson's disease & Movement Disorders Unit, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Neurology Service, Barcelona, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ezquerra+M%22">Ezquerra M</searchLink>; Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, University of Barcelona, Institut de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor+P%22">Pastor P</searchLink>; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.; Department of Neurology, Movement Disorders Unit, University Hospital Mútua de Terrassa, Terrassa, Spain.<br /><searchLink fieldCode="AU" term="%22Ran+C%22">Ran C</searchLink>; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Belin+AC%22">Belin AC</searchLink>; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Puschmann+A%22">Puschmann A</searchLink>; Department of Clinical Sciences Lund, Division of Neurology, Lund University, Lund, Sweden.; Department of Neurology, Skåne University Hospital, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Clarke+CE%22">Clarke CE</searchLink>; University of Birmingham, Birmingham, United Kingdom.; Sandwell & West Birmingham Hospitals NHS Trust, West Bromwich, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morrison+KE%22">Morrison KE</searchLink>; Health and Life Sciences, Faculty of Medicine, Queens University, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tan+M%22">Tan M</searchLink>; Department of Clinical and Movement Neurosciences, University College London, UCL Queen Square Institute of Neurology, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Krainc+D%22">Krainc D</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Farrer+MJ%22">Farrer MJ</searchLink>; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Landoulsi+Z%22">Landoulsi Z</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Kruger+R%22">Kruger R</searchLink>; University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Translational Neuroscience, Luxembourg, Luxembourg.; Luxembourg Institute of Health, Transversal Translational Medicine, Strassen, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Gasser+T%22">Gasser T</searchLink>; Department for Neurodegenerative Diseases, University of Tübingen, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Elbaz+A%22">Elbaz A</searchLink>; Gustave Roussy, University of Paris-Saclay, UVSQ, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; University of Tübingen, Institute for Clinical Epidemiology and Applied Biometry, Centre for Genetic Epidemiology, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wirdefeldt+K%22">Wirdefeldt K</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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  Data: <searchLink fieldCode="CA" term="%22Comprehensive+Unbiased+Risk+Factor+Assessment+for+Genetics+and+Environment+in+Parkinson%27s+Disease+%28COURAGE-PD%29+Consortium%22">Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2026 May 28; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 May 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101675390 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2373-8057 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738057%22">23738057 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Parkinsons Dis <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41531-026-01398-5
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      – TitleFull: Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.
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            NameFull: Valente EM
      – PersonEntity:
          Name:
            NameFull: Petrucci S
      – PersonEntity:
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            NameFull: Straniero L
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            NameFull: Zecchinelli A
      – PersonEntity:
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            NameFull: Pezzoli G
      – PersonEntity:
          Name:
            NameFull: Brighina L
      – PersonEntity:
          Name:
            NameFull: Ferrarese C
      – PersonEntity:
          Name:
            NameFull: Annesi G
      – PersonEntity:
          Name:
            NameFull: Quattrone A
      – PersonEntity:
          Name:
            NameFull: Gagliardi M
      – PersonEntity:
          Name:
            NameFull: Matsuo H
      – PersonEntity:
          Name:
            NameFull: Nakayama A
      – PersonEntity:
          Name:
            NameFull: Hattori N
      – PersonEntity:
          Name:
            NameFull: Nishioka K
      – PersonEntity:
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            NameFull: Chung SJ
      – PersonEntity:
          Name:
            NameFull: Kim YJ
      – PersonEntity:
          Name:
            NameFull: Kolber P
      – PersonEntity:
          Name:
            NameFull: Van de Warrenburg BP
      – PersonEntity:
          Name:
            NameFull: Bloem BR
      – PersonEntity:
          Name:
            NameFull: Toft M
      – PersonEntity:
          Name:
            NameFull: Pihlstrøm L
      – PersonEntity:
          Name:
            NameFull: Correia Guedes L
      – PersonEntity:
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            NameFull: Ferreira JJ
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          Name:
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            NameFull: Pastor P
      – PersonEntity:
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            NameFull: Ran C
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            NameFull: Clarke CE
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          Name:
            NameFull: Morrison KE
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          Name:
            NameFull: Tan M
      – PersonEntity:
          Name:
            NameFull: Krainc D
      – PersonEntity:
          Name:
            NameFull: Farrer MJ
      – PersonEntity:
          Name:
            NameFull: Landoulsi Z
      – PersonEntity:
          Name:
            NameFull: Kruger R
      – PersonEntity:
          Name:
            NameFull: Gasser T
      – PersonEntity:
          Name:
            NameFull: Elbaz A
      – PersonEntity:
          Name:
            NameFull: Sharma M
      – PersonEntity:
          Name:
            NameFull: Wirdefeldt K
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 05
              Text: 2026 May 28
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2373-8057
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: NPJ Parkinson's disease
              Type: main
ResultId 1