Bilobalide increases SKCa current via 5-HT2BR-PLC-PKC pathway, causing hyperpolarization and enhanced EET production in human coronary artery endothelial cells.

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Title: Bilobalide increases SKCa current via 5-HT2BR-PLC-PKC pathway, causing hyperpolarization and enhanced EET production in human coronary artery endothelial cells.
Authors: Ruamyod K; Siriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand., Taokum P; Siriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand., Wongsatan N; Siriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand., Tapechum S; Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand., Watanapa WB; Siriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand. wattana.wat@mahidol.ac.th.
Source: BMC complementary medicine and therapies [BMC Complement Med Ther] 2026 May 28; Vol. 26 (1). Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-7671
DOI:10.1186/s12906-026-05418-y