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Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.

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Title: Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Authors: Weng CH; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Schochet C; Department of Medicine at Weill Cornell Medicine, New York, NY, USA., Panneton V; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Assouvie A; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Eghbali S; Department of Medicine at Weill Cornell Medicine, New York, NY, USA., Monette S; Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, USA., Liu C; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Marouf Y; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Mangarin L; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Morgado-Palacin L; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Abrahimi P; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Urology, Weill Cornell Medicine, New York, NY, USA., Khan JF; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Hackett CS; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Medicine at Weill Cornell Medicine, New York, NY, USA., Hua D; Department of Medicine at Weill Cornell Medicine, New York, NY, USA., Lin Q; Department of Medicine at Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Hamadene L; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Holland PM; Surface Oncology Inc., Cambridge, MA, USA., Wolchok JD; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Medicine at Weill Cornell Medicine, New York, NY, USA. Electronic address: jwolchok@med.cornell.edu., Merghoub T; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: tmerghoub@med.cornell.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117443. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
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  Data: <searchLink fieldCode="AU" term="%22Weng+CH%22">Weng CH</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schochet+C%22">Schochet C</searchLink>; Department of Medicine at Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Panneton+V%22">Panneton V</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Assouvie+A%22">Assouvie A</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Eghbali+S%22">Eghbali S</searchLink>; Department of Medicine at Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Monette+S%22">Monette S</searchLink>; Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marouf+Y%22">Marouf Y</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mangarin+L%22">Mangarin L</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Morgado-Palacin+L%22">Morgado-Palacin L</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abrahimi+P%22">Abrahimi P</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Urology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Khan+JF%22">Khan JF</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hackett+CS%22">Hackett CS</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Medicine at Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hua+D%22">Hua D</searchLink>; Department of Medicine at Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lin+Q%22">Lin Q</searchLink>; Department of Medicine at Memorial Sloan-Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hamadene+L%22">Hamadene L</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Holland+PM%22">Holland PM</searchLink>; Surface Oncology Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wolchok+JD%22">Wolchok JD</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Medicine at Weill Cornell Medicine, New York, NY, USA. Electronic address: jwolchok@med.cornell.edu.<br /><searchLink fieldCode="AU" term="%22Merghoub+T%22">Merghoub T</searchLink>; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Parker Institute for Cancer Immunotherapy and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address: tmerghoub@med.cornell.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117443. <i>Date of Electronic Publication: </i>2026 May 29.
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