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Asthma exacerbation profile of benralizumab for severe eosinophilic asthma (the BenRex study): a multicentre, prospective cohort study.

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Title: Asthma exacerbation profile of benralizumab for severe eosinophilic asthma (the BenRex study): a multicentre, prospective cohort study.
Authors: Logan J; Gartnavel General Hospital, Glasgow, UK., Martin K; Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Gillespie L; NHS GGC Research and Innovation, Glasgow, UK., McConnachie A; Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Lee WN; Gartnavel General Hospital, Glasgow, UK., Burhan H; Royal Liverpool University Hospital, Liverpool, UK; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK., Brown T; Queen Alexandra Hospital, Portsmouth, UK., Faruqi S; Hull Royal Infirmary, Hull University Teaching Hospitals NHS Trust, Hull, UK., Jackson DJ; School of Immunology & Microbial Sciences, Guy's Hospital, King's College London, London, UK., Kurukulaaratchy R; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK; The David Hide Asthma & Allergy Research Centre, St Mary's Hospital, Newport, UK., Mansur AH; Heartlands Hospital, Birmingham, UK., Saralaya D; National Institute for Health Research National Commercial Research Delivery Centre, Bradford, UK., Fowler SJ; National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK; The University of Manchester, School of Biological Sciences, Division of Immunology, Immunity to Infection and Respiratory Medicine, Manchester, UK., Patel P; Royal Brompton and Harefield Hospitals, London, UK., Brown J; Royal Free London NHS Foundation Trust, London, UK., Lordan J; Freeman Hospital, Newcastle, UK., Siddiqui S; Imperial College London, Royal Brompton and Hammersmith Hospitals, London, UK., Smith SJ; Gartnavel General Hospital, Glasgow, UK., Shah PA; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK., Haldar K; Gartnavel General Hospital, Glasgow, UK., Megremis S; Department of Genetics and Genome Biology, Centre for Phage Research, Institute for Precision Health, University of Leicester, Leicester, UK., Harrison SA; Department of Genetics and Genome Biology, Centre for Phage Research, Institute for Precision Health, University of Leicester, Leicester, UK., Brown R; Centre of Genomic Research, University of Liverpool, Liverpool, UK., Nelson C; Centre of Genomic Research, University of Liverpool, Liverpool, UK., Mistry V; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK., Brown V; Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Chalmers JD; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Dundee, UK., Djukanovic R; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK., Pavord ID; Respiratory Medicine Unit and Oxford Respiratory National Institute for Health Research Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK., Heaney LG; Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Brightling CE; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK., Chaudhuri R; School of Infection & Immunity, University of Glasgow, Glasgow, UK. Electronic address: rekha.chaudhuri@nhs.scot.
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
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  Data: Asthma exacerbation profile of benralizumab for severe eosinophilic asthma (the BenRex study): a multicentre, prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Logan+J%22">Logan J</searchLink>; Gartnavel General Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Martin+K%22">Martin K</searchLink>; Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gillespie+L%22">Gillespie L</searchLink>; NHS GGC Research and Innovation, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22McConnachie+A%22">McConnachie A</searchLink>; Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lee+WN%22">Lee WN</searchLink>; Gartnavel General Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Burhan+H%22">Burhan H</searchLink>; Royal Liverpool University Hospital, Liverpool, UK; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Brown+T%22">Brown T</searchLink>; Queen Alexandra Hospital, Portsmouth, UK.<br /><searchLink fieldCode="AU" term="%22Faruqi+S%22">Faruqi S</searchLink>; Hull Royal Infirmary, Hull University Teaching Hospitals NHS Trust, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Jackson+DJ%22">Jackson DJ</searchLink>; School of Immunology & Microbial Sciences, Guy's Hospital, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kurukulaaratchy+R%22">Kurukulaaratchy R</searchLink>; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK; The David Hide Asthma & Allergy Research Centre, St Mary's Hospital, Newport, UK.<br /><searchLink fieldCode="AU" term="%22Mansur+AH%22">Mansur AH</searchLink>; Heartlands Hospital, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Saralaya+D%22">Saralaya D</searchLink>; National Institute for Health Research National Commercial Research Delivery Centre, Bradford, UK.<br /><searchLink fieldCode="AU" term="%22Fowler+SJ%22">Fowler SJ</searchLink>; National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK; The University of Manchester, School of Biological Sciences, Division of Immunology, Immunity to Infection and Respiratory Medicine, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Royal Brompton and Harefield Hospitals, London, UK.<br /><searchLink fieldCode="AU" term="%22Brown+J%22">Brown J</searchLink>; Royal Free London NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lordan+J%22">Lordan J</searchLink>; Freeman Hospital, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Siddiqui+S%22">Siddiqui S</searchLink>; Imperial College London, Royal Brompton and Hammersmith Hospitals, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+SJ%22">Smith SJ</searchLink>; Gartnavel General Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Shah+PA%22">Shah PA</searchLink>; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Haldar+K%22">Haldar K</searchLink>; Gartnavel General Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Megremis+S%22">Megremis S</searchLink>; Department of Genetics and Genome Biology, Centre for Phage Research, Institute for Precision Health, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Harrison+SA%22">Harrison SA</searchLink>; Department of Genetics and Genome Biology, Centre for Phage Research, Institute for Precision Health, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Brown+R%22">Brown R</searchLink>; Centre of Genomic Research, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Nelson+C%22">Nelson C</searchLink>; Centre of Genomic Research, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Mistry+V%22">Mistry V</searchLink>; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Brown+V%22">Brown V</searchLink>; Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Chalmers+JD%22">Chalmers JD</searchLink>; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Djukanovic+R%22">Djukanovic R</searchLink>; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health Research Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Pavord+ID%22">Pavord ID</searchLink>; Respiratory Medicine Unit and Oxford Respiratory National Institute for Health Research Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Heaney+LG%22">Heaney LG</searchLink>; Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Brightling+CE%22">Brightling CE</searchLink>; Institute for Lung Health, National Institute for Health Research Biomedical Research Centre, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Chaudhuri+R%22">Chaudhuri R</searchLink>; School of Infection & Immunity, University of Glasgow, Glasgow, UK. Electronic address: rekha.chaudhuri@nhs.scot.
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  Data: <searchLink fieldCode="JN" term="%22101605555%22">The Lancet. Respiratory medicine</searchLink> [Lancet Respir Med] 2026 May 29. <i>Date of Electronic Publication: </i>2026 May 29.
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