Nociceptin/orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli.

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Title: Nociceptin/orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli.
Authors: Hur KH; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Behavioral Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA.; Behavioral Biology Program, McLean Hospital, Belmont, MA, USA., Pizzagalli DA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California, Irvine, CA, USA., Stover J; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Behavioral Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA.; Behavioral Biology Program, McLean Hospital, Belmont, MA, USA., Cayetano K; McLean Imaging Center, McLean Hospital, Belmont, MA, USA., Kohut SJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. skohut@mclean.harvard.edu.; Behavioral Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA. skohut@mclean.harvard.edu.; Behavioral Biology Program, McLean Hospital, Belmont, MA, USA. skohut@mclean.harvard.edu.; McLean Imaging Center, McLean Hospital, Belmont, MA, USA. skohut@mclean.harvard.edu.
Source: Translational psychiatry [Transl Psychiatry] 2026 May 30; Vol. 16 (1). Date of Electronic Publication: 2026 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2158-3188
DOI:10.1038/s41398-026-04111-5