Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction.
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| Title: | Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction. |
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| Authors: | Duan J; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Jiang L; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Hu K; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Shi H; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Chi X; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Feng W; Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, China., Wang G; Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Xiang S; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Xiong B; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.; Guangxi Clinical Research Center for Critical Treatment of Major Infectious Diseases, Nanning, Guangxi, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 May 15; Vol. 17, pp. 1809540. Date of Electronic Publication: 2026 May 15 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1809540 |
