Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction.
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| Title: | Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction. |
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| Authors: | Duan J; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Jiang L; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Hu K; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Shi H; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Chi X; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Feng W; Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, China., Wang G; Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China., Xiang S; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China., Xiong B; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.; Guangxi Clinical Research Center for Critical Treatment of Major Infectious Diseases, Nanning, Guangxi, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 May 15; Vol. 17, pp. 1809540. Date of Electronic Publication: 2026 May 15 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42220532 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Chi+X%22">Chi X</searchLink>; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Institute of Infectious Diseases and Emergency and Critical Care Medicine, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Feng+W%22">Feng W</searchLink>; Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Guangxi Zhuang Autonomous Region Engineering Research Center for 3D Printing in Smart Biomanufacturing and Application, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Xiang+S%22">Xiang S</searchLink>; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.<br /><searchLink fieldCode="AU" term="%22Xiong+B%22">Xiong B</searchLink>; Guangxi Health Commission Key Laboratory of Diagnosis and Treatment of Acute Respiratory Distress Syndrome, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.; Department of Intensive Care Unit, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.; Guangxi Clinical Research Center for Critical Treatment of Major Infectious Diseases, Nanning, Guangxi, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 May 15; Vol. 17, pp. 1809540. <i>Date of Electronic Publication: </i>2026 May 15 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42220532 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fimmu.2026.1809540 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1809540 Titles: – TitleFull: Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Duan J – PersonEntity: Name: NameFull: Jiang L – PersonEntity: Name: NameFull: Hu K – PersonEntity: Name: NameFull: Shi H – PersonEntity: Name: NameFull: Chi X – PersonEntity: Name: NameFull: Feng W – PersonEntity: Name: NameFull: Wang G – PersonEntity: Name: NameFull: Xiang S – PersonEntity: Name: NameFull: Xiong B IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: 2026 May 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1664-3224 Numbering: – Type: volume Value: 17 Titles: – TitleFull: Frontiers in immunology Type: main |
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