Geographic Atrophy in Patients with Age-Related Macular Degeneration Is Associated with Rare Variants in Complement Factor H and Complement Factor I.

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Title: Geographic Atrophy in Patients with Age-Related Macular Degeneration Is Associated with Rare Variants in Complement Factor H and Complement Factor I.
Authors: de Breuk A; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., de Jong S; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Bakker B; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Kersten E; Department of Ophthalmology, Rijnstate, Arnhem, The Netherlands., Luttikhuizen DT; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Fauser S; Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.; Roche Pharma Research and Early Development, F. Hoffmann-La Roche, Basel, Switzerland., Klaver CCW; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland., den Hollander AI; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.; Ophthalmology Research, Sanofi, Cambridge, Massachusetts., Hoyng CB; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands., Lechanteur YTE; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.
Source: Ophthalmology science [Ophthalmol Sci] 2026 Mar 27; Vol. 6 (6), pp. 101171. Date of Electronic Publication: 2026 Mar 27 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-9145
DOI:10.1016/j.xops.2026.101171