Innovation in sepsis trials: rethinking endpoints, statistics and patient stratification.
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| Title: | Innovation in sepsis trials: rethinking endpoints, statistics and patient stratification. |
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| Authors: | David S; Institute of Intensive Care Medicine, University Hospital Zurich & University of Zurich, Rämistrasse 100, 8032, Zurich, Switzerland. Sascha.david@usz.ch.; Department of Nephrology, Medical School Hannover, Hannover, Germany. Sascha.david@usz.ch.; German Sepsis Society (DSG), Berlin, Germany. Sascha.david@usz.ch., Leone M; Department of Anesthesiology and Intensive Care Medicine, Nord Hospital, Assistance Publique Hôpitaux Universitaires de Marseille, Aix Marseille University, Marseille, France., Girardis M; Department of Anesthesia and ICU, University Hospital of Modena, Modena, Italy., Müller MM; Institute of Intensive Care Medicine, University Hospital Zurich & University of Zurich, Rämistrasse 100, 8032, Zurich, Switzerland., Gavrilovic S; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.; Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia., Domizi R; Clinic of Anesthesia and Intensive Care, Department of Biomedical Sciences and Public Health, Università Politecnica Delle Marche, Ancona, Italy.; Clinic of Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Delle Marche, Torrette, Italy., Damiani E; Clinic of Anesthesia and Intensive Care, Department of Biomedical Sciences and Public Health, Università Politecnica Delle Marche, Ancona, Italy.; Clinic of Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Delle Marche, Torrette, Italy., Martin-Loeches I; Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, Dublin, D08 NHY1, Ireland.; School of Medicine, Trinity College Dublin, Dublin, D02 PN40, Ireland.; Trinity Centre for Biomedical Engineering, Dublin, Ireland., Ferrer R; Intensive Care Department, Vall d'Hebron Hospital Universitari, SODIR Research Group, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.; Department of Medicine, Universitat Autònoma de Barcelona, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain., Bode C; Department of Anesthesiology and Intensive Care Medicine, University of Bonn, University Hospital Bonn, Bonn, Germany., Chousterman B; Université Paris Cité, INSERM U942 MASCOT, 75006, Paris, France.; Department of Anesthesia and Critical Care, AP-HP, Hôpital Lariboisière, 75010, Paris, France., Russell L; Department of Intensive Care, Herlev-Gentofte Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. |
| Source: | Intensive care medicine experimental [Intensive Care Med Exp] 2026 Jun 01; Vol. 14 (1). Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Springer-Verlag, GmbH Country of Publication: Germany NLM ID: 101645149 Publication Model: Electronic Cited Medium: Print ISSN: 2197-425X (Print) Linking ISSN: 2197425X NLM ISO Abbreviation: Intensive Care Med Exp Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2197-425X |
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| DOI: | 10.1186/s40635-026-00911-7 |