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Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio.

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Title: Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio.
Authors: Algeciras-Schimnich A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Bornhorst JA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Figdore DJ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Rea Reyes RE; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison., Ashrafzadeh-Kian S; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Wilson R; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison., Burkett BJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Johnson DR; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Botha H; Department of Neurology, Mayo Clinic, Rochester, Minnesota., McCarter SJ; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Day GS; Department of Neurology, Mayo Clinic, Jacksonville, Florida., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota.; Associate Editor, JAMA Neurology., Ramanan VK; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Johnson SC; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison., Zetterberg H; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, United Kingdom.; UK Dementia Research Institute, University College London, London, United Kingdom.; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota.
Source: JAMA neurology [JAMA Neurol] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
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  Data: Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio.
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  Data: <searchLink fieldCode="AU" term="%22Algeciras-Schimnich+A%22">Algeciras-Schimnich A</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Bornhorst+JA%22">Bornhorst JA</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Figdore+DJ%22">Figdore DJ</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Rea+Reyes+RE%22">Rea Reyes RE</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Ashrafzadeh-Kian+S%22">Ashrafzadeh-Kian S</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Burkett+BJ%22">Burkett BJ</searchLink>; Department of Radiology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Johnson+DR%22">Johnson DR</searchLink>; Department of Radiology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Botha+H%22">Botha H</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22McCarter+SJ%22">McCarter SJ</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Day+GS%22">Day GS</searchLink>; Department of Neurology, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Graff-Radford+J%22">Graff-Radford J</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.; Associate Editor, JAMA Neurology.<br /><searchLink fieldCode="AU" term="%22Ramanan+VK%22">Ramanan VK</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Jack+CR+Jr%22">Jack CR Jr</searchLink>; Department of Radiology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Wisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin, Madison.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, United Kingdom.; UK Dementia Research Institute, University College London, London, United Kingdom.; Centre for Brain Research, Indian Institute of Science, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Petersen+RC%22">Petersen RC</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota.
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