Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.
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| Title: | Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity. |
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| Authors: | Skordos I; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Gilis E; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium., Callewaert C; Ghent University, Center for Microbial Ecology and Technology, Ghent, Belgium., Aidarova A; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Haegman M; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Driege Y; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Kreike M; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Afonina IS; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Staal J; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium., Demeyer A; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium.; Ghent University, Department of Head and Skin, Ghent, Belgium., Elewaut D; Molecular Immunology and Inflammation Unit, VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Ghent University, Department of Rheumatology, Department of Internal Medicine and Pediatrics, Ghent, Belgium., Beyaert R; Unit of Molecular Signal Transduction in Inflammation, VIB Center for Inflammation Research, VIB, Ghent, Belgium. rudi@irc.vib-ugent.be.; Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium. rudi@irc.vib-ugent.be. |
| Source: | EMBO reports [EMBO Rep] 2026 Jul; Vol. 27 (13), pp. 3731-3758. Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.1038/s44319-026-00814-4 |
