Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

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Title: Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.
Authors: De Pascale G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy. gennaro.depascalemd@gmail.com.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. gennaro.depascalemd@gmail.com., Cutuli SL; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Vargas M; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy., Cortegiani A; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Dalfino L; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy., Greco M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy., Baroni S; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Esposito C; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy., Grieco DL; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Grinberg R; Shamir Medical Center, General Intensive Care Unit, Zriffin, Israel.; Gray School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Lombardi G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Pota V; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy., Presti G; General Intensive Care Unit, University Hospital Policlinico Paolo Giaccone, Palermo, Italy.; Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Palermo, Italy., Stufano M; Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Intensive Care Unit, University Hospital Policlinico, Bari, Italy., Tanzarella ES; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Corcione A; Department of Critical Care, Anaesthesia and Postoperative Unit, AO Ospedali dei Colli, Presidio Monaldi, Naples, Italy., Pace C; Department of Woman, Child, General and Specialized Surgery, Università degli studi della Campania L. Vanvitelli, Naples, Italy., Sanguinetti M; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bove T; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Urbani A; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Laboratory and Hematological Sciences, Unit of Chemistry, Biochemistry and Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Girardis M; Department of Anaesthesiology and Intensive Care, University Hospital of Modena, University of Modena and Reggio Emilia, Modena, Italy., Cecconi M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of Anaesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy., Servillo G; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy., Conti G; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Antonelli M; Department of Biotechnologies, Intensive Care and Perioperative Medicine, Catholic University of the Sacred Heart, Rome, Italy.; Department of Emergency Sciences, Anaesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Corporate Authors: MICROINHALO study group
Source: Intensive care medicine [Intensive Care Med] 2026 Jun; Vol. 52 (6), pp. 1235-1247. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-1238
DOI:10.1007/s00134-026-08459-6