Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells.

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Title: Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells.
Authors: Travers J; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Zhang Y; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Cajigas-Du Ross CK; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Huang E; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., McMullen MR; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Wu J; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Biomedical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA., Paouri E; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Davalos D; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Wu X; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Microbial Science in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Pathak V; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Rotroff DM; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Center for Quantitative Metabolic Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Nagy LE; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-3350
DOI:10.1097/HEP.0000000000001803