Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells.
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| Title: | Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells. |
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| Authors: | Travers J; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Zhang Y; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Cajigas-Du Ross CK; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Huang E; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., McMullen MR; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Wu J; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Biomedical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA., Paouri E; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Davalos D; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Wu X; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Microbial Science in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Pathak V; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Rotroff DM; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Center for Quantitative Metabolic Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Nagy LE; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA. |
| Source: | Hepatology (Baltimore, Md.) [Hepatology] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42228943 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Travers+J%22">Travers J</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Gastroenterology and Liver Disease, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Cajigas-Du+Ross+CK%22">Cajigas-Du Ross CK</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Huang+E%22">Huang E</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22McMullen+MR%22">McMullen MR</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Biomedical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Paouri+E%22">Paouri E</searchLink>; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Davalos+D%22">Davalos D</searchLink>; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Neurosciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Microbial Science in Health, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Pathak+V%22">Pathak V</searchLink>; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Rotroff+DM%22">Rotroff DM</searchLink>; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Center for Quantitative Metabolic Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Nagy+LE%22">Nagy LE</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228302946%22">Hepatology (Baltimore, Md.)</searchLink> [Hepatology] 2026 Jun 02. <i>Date of Electronic Publication: </i>2026 Jun 02. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8302946 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-3350 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202709139%22">02709139 </searchLink><i>NLM ISO Abbreviation: </i>Hepatology <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42228943 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1097/HEP.0000000000001803 Languages: – Code: eng Text: English Titles: – TitleFull: Non-transcriptional activity of IRF3 promotes liver fibrosis and stress granule assembly via a dsRNA-TLR3-dependent pathway in hepatic stellate cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Travers J – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Cajigas-Du Ross CK – PersonEntity: Name: NameFull: Huang E – PersonEntity: Name: NameFull: McMullen MR – PersonEntity: Name: NameFull: Wu J – PersonEntity: Name: NameFull: Paouri E – PersonEntity: Name: NameFull: Davalos D – PersonEntity: Name: NameFull: Wu X – PersonEntity: Name: NameFull: Pathak V – PersonEntity: Name: NameFull: Rotroff DM – PersonEntity: Name: NameFull: Nagy LE IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 06 Text: 2026 Jun 02 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1527-3350 Titles: – TitleFull: Hepatology (Baltimore, Md.) Type: main |
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