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Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity.

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Title: Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity.
Authors: Yu X; Changping Laboratory, Beijing, China., Liao H; Changping Laboratory, Beijing, China., Lv J; Changping Laboratory, Beijing, China., Sun Y; Changping Laboratory, Beijing, China., Zhang R; Changping Laboratory, Beijing, China., Chen Y; Changping Laboratory, Beijing, China., Lin Y; Changping Laboratory, Beijing, China., Liu L; Changping Laboratory, Beijing, China., Li S; Changping Laboratory, Beijing, China.; Center for Cancer Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China., Tang H; Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Jia P; Changping Laboratory, Beijing, China.; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China., Shao B; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China., Yang Z; Changping Laboratory, Beijing, China., Fu YX; Changping Laboratory, Beijing, China. yangxinfu@mail.tsinghua.edu.cn.; Center for Cancer Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China. yangxinfu@mail.tsinghua.edu.cn.; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China. yangxinfu@mail.tsinghua.edu.cn., Ren Z; Changping Laboratory, Beijing, China. renzhenhua@cpl.ac.cn.; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China. renzhenhua@cpl.ac.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 02; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liao+H%22">Liao H</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lv+J%22">Lv J</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Changping Laboratory, Beijing, China.; Center for Cancer Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jia+P%22">Jia P</searchLink>; Changping Laboratory, Beijing, China.; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shao+B%22">Shao B</searchLink>; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Changping Laboratory, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+YX%22">Fu YX</searchLink>; Changping Laboratory, Beijing, China. yangxinfu@mail.tsinghua.edu.cn.; Center for Cancer Biology, School of Basic Medical Sciences, Tsinghua University, Beijing, China. yangxinfu@mail.tsinghua.edu.cn.; State Key Laboratory of Molecular Oncology, Tsinghua University, Beijing, China. yangxinfu@mail.tsinghua.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ren+Z%22">Ren Z</searchLink>; Changping Laboratory, Beijing, China. renzhenhua@cpl.ac.cn.; Department of Lymphoma, Department of Breast Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China. renzhenhua@cpl.ac.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 02
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