View in EDS HTML Full Text PDF Full Text

Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.

Saved in:
Bibliographic Details
Title: Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
Authors: Perry TA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. thomas.perry@kennedy.ox.ac.uk., Deng Y; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Hulley PA; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Maciewicz RA; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Mitchelmore J; Novartis Biomedical Research, Basel, Switzerland., Larsson S; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Gogain J; Standard BioTools (previously known as SomaLogic), Boulder, Colorado, USA., Brachat S; Novartis Biomedical Research, Basel, Switzerland., Struglics A; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Appleton CT; Department of Medicine, University of Western Ontario, London, Ontario, Canada., Kluzek S; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; NIHR Nottingham Biomedical Research Centre and Versus Arthritis Sport, Exercise and Osteoarthritis Centre, University of Nottingham, Nottingham, UK., Arden NK; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, UK., Felson D; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA., Bondi L; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Kapoor M; Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada., Lohmander LS; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden., Welting TJ; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University, Maastricht, Netherlands., Walsh DA; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.; Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, UK., Valdes AM; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK., Jostins-Dean L; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK., Watt FE; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Tom BDM; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Vincent TL; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. tonia.vincent@kennedy.ox.ac.uk.
Corporate Authors: STEpUP OA Consortium
Source: Nature communications [Nat Commun] 2026 Jun 02; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42230587
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Perry+TA%22">Perry TA</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. thomas.perry@kennedy.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Deng+Y%22">Deng Y</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hulley+PA%22">Hulley PA</searchLink>; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maciewicz+RA%22">Maciewicz RA</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mitchelmore+J%22">Mitchelmore J</searchLink>; Novartis Biomedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Larsson+S%22">Larsson S</searchLink>; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Gogain+J%22">Gogain J</searchLink>; Standard BioTools (previously known as SomaLogic), Boulder, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Brachat+S%22">Brachat S</searchLink>; Novartis Biomedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Struglics+A%22">Struglics A</searchLink>; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Appleton+CT%22">Appleton CT</searchLink>; Department of Medicine, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kluzek+S%22">Kluzek S</searchLink>; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; NIHR Nottingham Biomedical Research Centre and Versus Arthritis Sport, Exercise and Osteoarthritis Centre, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Arden+NK%22">Arden NK</searchLink>; Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Felson+D%22">Felson D</searchLink>; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bondi+L%22">Bondi L</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Kapoor+M%22">Kapoor M</searchLink>; Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lohmander+LS%22">Lohmander LS</searchLink>; Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Welting+TJ%22">Welting TJ</searchLink>; Laboratory for Experimental Orthopedics, Department of Orthopedic Surgery, Maastricht University, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Walsh+DA%22">Walsh DA</searchLink>; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.; Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, UK.<br /><searchLink fieldCode="AU" term="%22Valdes+AM%22">Valdes AM</searchLink>; Pain Centre Versus Arthritis, Advanced Pain Discovery Platform, and the NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Jostins-Dean+L%22">Jostins-Dean L</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Watt+FE%22">Watt FE</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tom+BDM%22">Tom BDM</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vincent+TL%22">Vincent TL</searchLink>; Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK. tonia.vincent@kennedy.ox.ac.uk.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22STEpUP+OA+Consortium%22">STEpUP OA Consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jun 02; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jun 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42230587
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-71632-4
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Perry TA
      – PersonEntity:
          Name:
            NameFull: Deng Y
      – PersonEntity:
          Name:
            NameFull: Hulley PA
      – PersonEntity:
          Name:
            NameFull: Maciewicz RA
      – PersonEntity:
          Name:
            NameFull: Mitchelmore J
      – PersonEntity:
          Name:
            NameFull: Larsson S
      – PersonEntity:
          Name:
            NameFull: Gogain J
      – PersonEntity:
          Name:
            NameFull: Brachat S
      – PersonEntity:
          Name:
            NameFull: Struglics A
      – PersonEntity:
          Name:
            NameFull: Appleton CT
      – PersonEntity:
          Name:
            NameFull: Kluzek S
      – PersonEntity:
          Name:
            NameFull: Arden NK
      – PersonEntity:
          Name:
            NameFull: Felson D
      – PersonEntity:
          Name:
            NameFull: Bondi L
      – PersonEntity:
          Name:
            NameFull: Kapoor M
      – PersonEntity:
          Name:
            NameFull: Lohmander LS
      – PersonEntity:
          Name:
            NameFull: Welting TJ
      – PersonEntity:
          Name:
            NameFull: Walsh DA
      – PersonEntity:
          Name:
            NameFull: Valdes AM
      – PersonEntity:
          Name:
            NameFull: Jostins-Dean L
      – PersonEntity:
          Name:
            NameFull: Watt FE
      – PersonEntity:
          Name:
            NameFull: Tom BDM
      – PersonEntity:
          Name:
            NameFull: Vincent TL
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 06
              Text: 2026 Jun 02
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1