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Progranulin deficiency induces premature vascular senescence and dysfunction.

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Title: Progranulin deficiency induces premature vascular senescence and dysfunction.
Authors: Luvizotto RAM; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil., Nascimento AF; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil., Pimenta GF; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., de Costa RM; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Jatai, Jatai, Brazil., Beling T; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States., Singh S; Children's Hospital of Philadelphia (CHOP), Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States., Alves JV; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Awata WMC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Russ A; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States., Haastrup AI; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States., Cuevas RA; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Behzadi P; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., St Hilaire C; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States., Roberts JT; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States., Bruder A; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States., Bruder-Nascimento T; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States.
Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Jul 01; Vol. 331 (1), pp. H260-H275. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Progranulin deficiency induces premature vascular senescence and dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Luvizotto+RAM%22">Luvizotto RAM</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil.<br /><searchLink fieldCode="AU" term="%22Nascimento+AF%22">Nascimento AF</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Brazil.<br /><searchLink fieldCode="AU" term="%22Pimenta+GF%22">Pimenta GF</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Costa+RM%22">de Costa RM</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Institute of Health Sciences, Federal University of Jatai, Jatai, Brazil.<br /><searchLink fieldCode="AU" term="%22Beling+T%22">Beling T</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Children's Hospital of Philadelphia (CHOP), Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22Alves+JV%22">Alves JV</searchLink>; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Awata+WMC%22">Awata WMC</searchLink>; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Russ+A%22">Russ A</searchLink>; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States.<br /><searchLink fieldCode="AU" term="%22Haastrup+AI%22">Haastrup AI</searchLink>; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States.<br /><searchLink fieldCode="AU" term="%22Cuevas+RA%22">Cuevas RA</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22Behzadi+P%22">Behzadi P</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22St+Hilaire+C%22">St Hilaire C</searchLink>; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.; Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.<br /><searchLink fieldCode="AU" term="%22Roberts+JT%22">Roberts JT</searchLink>; Department of Pharmacology, University of South Alabama, Mobile, Alabama, United States.<br /><searchLink fieldCode="AU" term="%22Bruder+A%22">Bruder A</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.<br /><searchLink fieldCode="AU" term="%22Bruder-Nascimento+T%22">Bruder-Nascimento T</searchLink>; Department of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama, United States.; Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States.
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  Data: <searchLink fieldCode="JN" term="%22100901228%22">American journal of physiology. Heart and circulatory physiology</searchLink> [Am J Physiol Heart Circ Physiol] 2026 Jul 01; Vol. 331 (1), pp. H260-H275. <i>Date of Electronic Publication: </i>2026 Jun 03.
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        Value: 10.1152/ajpheart.00012.2026
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        Text: English
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      – TitleFull: Progranulin deficiency induces premature vascular senescence and dysfunction.
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