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CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.

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Title: CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.
Authors: Sakuma I; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. Electronic address: ikki.sakuma@yale.edu., Gaspar RC; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Morgan HN; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Zheng J; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Nasiri AR; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Dufour S; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Kahn M; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Guerra MT; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Taki Y; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan., Kawashima Y; Kazusa DNA Research Institute, Chiba 292-0818, Japan., Yimlamai D; Departments of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA., Perelis M; Ionis Pharmaceuticals, Carlsbad, CA, USA., Vatner DF; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Petersen KF; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Samuel VT; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; West Haven VA Medical Center, West Haven, CT, USA., Tanaka T; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan., Shulman GI; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: gerald.shulman@yale.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117369. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.
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  Data: <searchLink fieldCode="AU" term="%22Sakuma+I%22">Sakuma I</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. Electronic address: ikki.sakuma@yale.edu.<br /><searchLink fieldCode="AU" term="%22Gaspar+RC%22">Gaspar RC</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+HN%22">Morgan HN</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Nasiri+AR%22">Nasiri AR</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Dufour+S%22">Dufour S</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+M%22">Kahn M</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Guerra+MT%22">Guerra MT</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Taki+Y%22">Taki Y</searchLink>; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Kawashima+Y%22">Kawashima Y</searchLink>; Kazusa DNA Research Institute, Chiba 292-0818, Japan.<br /><searchLink fieldCode="AU" term="%22Yimlamai+D%22">Yimlamai D</searchLink>; Departments of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Perelis+M%22">Perelis M</searchLink>; Ionis Pharmaceuticals, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vatner+DF%22">Vatner DF</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+KF%22">Petersen KF</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Samuel+VT%22">Samuel VT</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; West Haven VA Medical Center, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Departments of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Shulman+GI%22">Shulman GI</searchLink>; Departments of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Departments of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: gerald.shulman@yale.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117369. <i>Date of Electronic Publication: </i>2026 Jun 03.
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