Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer.
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| Title: | Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. |
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| Authors: | Liu Y; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA chumsri.saranya@mayo.edu Liu.Yi1@mayo.edu.; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA., Carter JM; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada., Ma Y; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA., Deshmukh SK; Caris Life Sciences Inc Phoenix, Phoenix, Arizona, USA., Sledge GW Jr; Caris Life Sciences Inc Phoenix, Phoenix, Arizona, USA., Balko JM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kachergus JM; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA., Shi J; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA., Gregory M; NanoString Technologies Inc, Seattle, Washington, USA., Gong J; NanoString Technologies Inc, Seattle, Washington, USA., Joensuu H; Department of Oncology, HUS Helsinki University Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland., Perez EA; Department of Cancer Biology, Mayo Clinic in Florida, Jacksonville, Florida, USA., Stover D; The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio, USA., Carey L; UNC School of Medicine, Chapel Hill, North Carolina, USA., Sikov WM; Department of Medicine, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.; Women & Infants Hospital of Rhode Island, Providence, Rhode Island, USA., Leon-Ferre R; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA., Knutson KL; Department of Immunology, Mayo Clinic in Florida, Jacksonville, Florida, USA., Boughey JC; Department of Surgery, Mayo Clinic Rochester, Rochester, Minnesota, USA., Ingle JN; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA., Kalari KR; Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA., Couch FJ; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, Minnesota, USA., Asmann YW; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA., Goetz MP; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA., Thompson EA; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA.; Department of Cancer Biology, Mayo Clinic in Florida, Jacksonville, Florida, USA., Chumsri S; Department of Hematology and Oncology, Mayo Clinic in Florida, Jacksonville, Florida, USA chumsri.saranya@mayo.edu Liu.Yi1@mayo.edu. |
| Source: | Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jun 03; Vol. 14 (6). Date of Electronic Publication: 2026 Jun 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42236117 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA chumsri.saranya@mayo.edu Liu.Yi1@mayo.edu.; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Carter+JM%22">Carter JM</searchLink>; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Deshmukh+SK%22">Deshmukh SK</searchLink>; Caris Life Sciences Inc Phoenix, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Sledge+GW+Jr%22">Sledge GW Jr</searchLink>; Caris Life Sciences Inc Phoenix, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Balko+JM%22">Balko JM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Kachergus+JM%22">Kachergus JM</searchLink>; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Gregory+M%22">Gregory M</searchLink>; NanoString Technologies Inc, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Gong+J%22">Gong J</searchLink>; NanoString Technologies Inc, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Joensuu+H%22">Joensuu H</searchLink>; Department of Oncology, HUS Helsinki University Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Perez+EA%22">Perez EA</searchLink>; Department of Cancer Biology, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Stover+D%22">Stover D</searchLink>; The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Carey+L%22">Carey L</searchLink>; UNC School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Sikov+WM%22">Sikov WM</searchLink>; Department of Medicine, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.; Women & Infants Hospital of Rhode Island, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Leon-Ferre+R%22">Leon-Ferre R</searchLink>; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Knutson+KL%22">Knutson KL</searchLink>; Department of Immunology, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Boughey+JC%22">Boughey JC</searchLink>; Department of Surgery, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Ingle+JN%22">Ingle JN</searchLink>; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Kalari+KR%22">Kalari KR</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Couch+FJ%22">Couch FJ</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Asmann+YW%22">Asmann YW</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Goetz+MP%22">Goetz MP</searchLink>; Department of Oncology, Mayo Clinic Rochester, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+EA%22">Thompson EA</searchLink>; Department of Pioneering Science, Office of Core Shared Services, Mayo Clinic in Florida, Jacksonville, Florida, USA.; Department of Cancer Biology, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Chumsri+S%22">Chumsri S</searchLink>; Department of Hematology and Oncology, Mayo Clinic in Florida, Jacksonville, Florida, USA chumsri.saranya@mayo.edu Liu.Yi1@mayo.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jun 03; Vol. 14 (6). <i>Date of Electronic Publication: </i>2026 Jun 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42236117 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/jitc-2025-014020 Languages: – Code: eng Text: English Titles: – TitleFull: Spatially resolved single-cell landscape of tumor immunotypes reveals the central role of interferon signaling and plasmacytoid dendritic cells in triple-negative breast cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Liu Y – PersonEntity: Name: NameFull: Carter JM – PersonEntity: Name: NameFull: Ma Y – PersonEntity: Name: NameFull: Deshmukh SK – PersonEntity: Name: NameFull: Sledge GW Jr – PersonEntity: Name: NameFull: Balko JM – PersonEntity: Name: NameFull: Kachergus JM – PersonEntity: Name: NameFull: Shi J – PersonEntity: Name: NameFull: Gregory M – PersonEntity: Name: NameFull: Gong J – PersonEntity: Name: NameFull: Joensuu H – PersonEntity: Name: NameFull: Perez EA – PersonEntity: Name: NameFull: Stover D – PersonEntity: Name: NameFull: Carey L – PersonEntity: Name: NameFull: Sikov WM – PersonEntity: Name: NameFull: Leon-Ferre R – PersonEntity: Name: NameFull: Knutson KL – PersonEntity: Name: NameFull: Boughey JC – PersonEntity: Name: NameFull: Ingle JN – PersonEntity: Name: NameFull: Kalari KR – PersonEntity: Name: NameFull: Couch FJ – PersonEntity: Name: NameFull: Asmann YW – PersonEntity: Name: NameFull: Goetz MP – PersonEntity: Name: NameFull: Thompson EA – PersonEntity: Name: NameFull: Chumsri S IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 06 Text: 2026 Jun 03 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2051-1426 Numbering: – Type: volume Value: 14 – Type: issue Value: 6 Titles: – TitleFull: Journal for immunotherapy of cancer Type: main |
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