A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.

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Title: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.
Authors: Kaur M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Travin DY; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Berger MJ; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Jangra M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Morici M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Safdari HA; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Klepacki D; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Wang W; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Cook M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Chou S; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Guitor AK; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Koteva K; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Xu M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Ejim L; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Fiebig A; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Yousefi Y; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Coombes BK; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Macneil L; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Vázquez-Laslop N; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Mankin AS; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu., Wilson DN; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. daniel.wilson@uni-hamburg.de., Wright GD; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8123), pp. 737-746. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-026-10589-2