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A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.

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Title: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.
Authors: Kaur M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Travin DY; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Berger MJ; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Jangra M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Morici M; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Safdari HA; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany., Klepacki D; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Wang W; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Cook M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Chou S; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Guitor AK; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Koteva K; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Xu M; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Ejim L; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Fiebig A; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Yousefi Y; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Coombes BK; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Macneil L; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Vázquez-Laslop N; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA., Mankin AS; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu., Wilson DN; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. daniel.wilson@uni-hamburg.de., Wright GD; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8123), pp. 737-746. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.
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  Data: <searchLink fieldCode="AU" term="%22Kaur+M%22">Kaur M</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Travin+DY%22">Travin DY</searchLink>; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Berger+MJ%22">Berger MJ</searchLink>; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jangra+M%22">Jangra M</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. 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DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Guitor+AK%22">Guitor AK</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Koteva+K%22">Koteva K</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. 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DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fiebig+A%22">Fiebig A</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yousefi+Y%22">Yousefi Y</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Coombes+BK%22">Coombes BK</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Macneil+L%22">Macneil L</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Vázquez-Laslop+N%22">Vázquez-Laslop N</searchLink>; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mankin+AS%22">Mankin AS</searchLink>; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu.<br /><searchLink fieldCode="AU" term="%22Wilson+DN%22">Wilson DN</searchLink>; Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. daniel.wilson@uni-hamburg.de.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.
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