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Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS-CoV-2 P.1 Variant in K18-hACE2 Mice.

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Title: Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS-CoV-2 P.1 Variant in K18-hACE2 Mice.
Authors: Angelim MKSC; Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Rodrigues PB; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Campos ATP; Physics Department, Federal University of Ceará (UFCE), Fortaleza, Ceará, Brazil., Gome GF; Ribeirão Preto Medical School, Center of Research in Inflammatory Diseases, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Souza GF; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Matheus VA; Advanced Therapies Laboratory, Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Cesar CL; Physics Department, Federal University of Ceará (UFCE), Fortaleza, Ceará, Brazil., Proença-Módena JL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil., Vinolo MAR; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil.
Source: Immunity, inflammation and disease [Immun Inflamm Dis] 2026 Jun; Vol. 14 (6), pp. e70457.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS-CoV-2 P.1 Variant in K18-hACE2 Mice.
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  Data: <searchLink fieldCode="AU" term="%22Angelim+MKSC%22">Angelim MKSC</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+PB%22">Rodrigues PB</searchLink>; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Campos+ATP%22">Campos ATP</searchLink>; Physics Department, Federal University of Ceará (UFCE), Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Gome+GF%22">Gome GF</searchLink>; Ribeirão Preto Medical School, Center of Research in Inflammatory Diseases, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+GF%22">Souza GF</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Matheus+VA%22">Matheus VA</searchLink>; Advanced Therapies Laboratory, Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cesar+CL%22">Cesar CL</searchLink>; Physics Department, Federal University of Ceará (UFCE), Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Proença-Módena+JL%22">Proença-Módena JL</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Vinolo+MAR%22">Vinolo MAR</searchLink>; Laboratory of Immunoinflammation, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes-Vieira+PM%22">Moraes-Vieira PM</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil.
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              Text: 2026 Jun
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